VEGFB and TNXB

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		VEGFB	TNXB
Description		vascular endothelial growth factor B	tenascin XB
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Collagen Fibril Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Platelet Degranulation Protein O-linked Glycosylation Vascular Endothelial Growth Factor Signaling Pathway Response To Drug Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development	Cell Adhesion Actin Cytoskeleton Organization Collagen Fibril Organization Collagen Metabolic Process Elastic Fiber Assembly
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	ECM proteoglycans
Drugs		Aflibercept
Diseases		Gastric cancer	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Apolipoprotein A1 levels ( 32203549) Crohn's disease ( 28067908) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549) Red blood cell count ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Age-related macular degeneration ( 22694956) Alzheimer's disease ( 30636644) Asthma ( 31619474) Atopic dermatitis ( 23886662) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 32469254) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil counts ( 27863252) Hemoglobin levels ( 32327693) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 30054594) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet distribution width ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Shingles ( 28928442) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26316170 26502338 21408207 28714469) Systolic blood pressure ( 28739976) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 27863252)
Interacting Genes		6 interacting genes: ADRB2 FLT1 KLHL12 NRP1 TNXB VEGFA	6 interacting genes: BANP CEACAM6 POU6F2 TGM7 VEGFA VEGFB
Entrez ID		7423	7148
HPRD ID		03237	02993
Ensembl ID		ENSG00000173511	ENSG00000168477
Uniprot IDs		P49765 Q7LAP4	O95680 O95681 P22105 Q6IPK3 Q9Y464
PDB IDs		2C7W 2VWE 2XAC	2CUH 2CUI 2CUM
Enriched GO Terms of Interacting Partners?
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