TUBG1 and WNT3

Data Source:
BioGRID (affinity chromatography technology)

		TUBG1	WNT3
Description		tubulin gamma 1	Wnt family member 3
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Spindle Polar Microtubule Cytosol Microtubule Recycling Endosome Mitotic Spindle Microtubule	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Wnt Signalosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding	Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Mitotic Spindle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Microtubule Organization Ciliary Basal Body-plasma Membrane Docking	Cell Morphogenesis Mesoderm Formation Gamete Generation Axon Guidance Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Positive Regulation Of Gene Expression Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Neuron Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Spemann Organizer Formation At The Anterior End Of The Primitive Streak Canonical Wnt Signaling Pathway Limb Bud Formation Head Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Stem Cell Proliferation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Stem Cell Proliferation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs		Vinblastine
Diseases			Tetra-amelia
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 30061737) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 28196072) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Parkinson's disease ( 22451204 21812969) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post bronchodilator FEV1 ( 26634245) Reaction time ( 29844566) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		28 interacting genes: APP BRCA1 CENPJ CNTN2 CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	1 interacting genes: FZD1
Entrez ID		7283	7473
HPRD ID		01853	01318
Ensembl ID		ENSG00000131462	ENSG00000108379
Uniprot IDs		P23258	P56703
PDB IDs		1Z5V 1Z5W 3CB2 6V5V 6V6S	6AHY
Enriched GO Terms of Interacting Partners?
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