TP53 and MAPK14

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology)

		TP53	MAPK14
Description		tumor protein p53	mitogen-activated protein kinase 14
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Replication Fork Transcription Regulator Complex Transcription Factor TFIID Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Centrosome Cytosol Nuclear Matrix Nuclear Body PML Body Protein-containing Complex Site Of Double-strand Break	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Speck Secretory Granule Lumen Glutamatergic Synapse Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding TFIID-class Transcription Factor Complex Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protease Binding P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity MRNA 3'-UTR Binding Copper Ion Binding Protein Binding ATP Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Regulator Activity Histone Acetyltransferase Binding Identical Protein Binding Histone Deacetylase Binding Protein Self-association Protein Heterodimerization Activity Protein N-terminus Binding Chaperone Binding Protein Phosphatase 2A Binding MDM2/MDM4 Family Protein Binding Disordered Domain Specific Binding Promoter-specific Chromatin Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase P38 Binding NFAT Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Strand Renaturation In Utero Embryonic Development Somitogenesis Release Of Cytochrome C From Mitochondria Hematopoietic Progenitor Cell Differentiation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment T Cell Lineage Commitment Response To Ischemia Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator ER Overload Response Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Ras Protein Signal Transduction Gastrulation Negative Regulation Of Neuroblast Proliferation Cell Aging Protein Localization Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan MRNA Transcription RRNA Transcription Response To Salt Stress Response To X-ray Response To Gamma Radiation Positive Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Viral Process Protein Deubiquitination Cytokine-mediated Signaling Pathway Cerebellum Development Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Chromatin Assembly Mitotic G1 DNA Damage Checkpoint T Cell Differentiation In Thymus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Tissue Remodeling Cellular Response To UV Multicellular Organism Growth Cellular Response To Drug Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Entrainment Of Circadian Clock By Photoperiod Mitochondrial DNA Repair Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Circadian Behavior Bone Marrow Development Embryonic Organ Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Helicase Activity Protein Tetramerization Neuron Apoptotic Process Negative Regulation Of Telomerase Activity Hematopoietic Stem Cell Differentiation Interferon-gamma-mediated Signaling Pathway Cardiac Septum Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Thymocyte Apoptotic Process Necroptotic Process Positive Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-C Mitotic Cell Cycle Arrest Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Actinomycin D Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Aging Replicative Senescence Oxidative Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Pentose-phosphate Shunt Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To DNA Damage Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Senescence Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	DNA Damage Checkpoint Activation Of MAPK Activity Cell Morphogenesis Cartilage Condensation Angiogenesis Placenta Development Chondrocyte Differentiation Glucose Metabolic Process Regulation Of Transcription By RNA Polymerase II Apoptotic Process Chemotaxis Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ras Protein Signal Transduction Skeletal Muscle Tissue Development Positive Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Peptidyl-serine Phosphorylation Fatty Acid Oxidation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Response To Muramyl Dipeptide Positive Regulation Of Interleukin-12 Production Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Muscle Stretch P38MAPK Cascade Positive Regulation Of Protein Import Into Nucleus Signal Transduction In Response To DNA Damage Neutrophil Degranulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Brown Fat Cell Differentiation Stress-induced Premature Senescence Cellular Response To Virus Regulation Of Synaptic Membrane Adhesion Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myoblast Fusion Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription Regulation of PTEN gene transcription Factors involved in megakaryocyte development and platelet production	NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation CD163 mediating an anti-inflammatory response
Drugs		Acetylsalicylic acid Zinc Triethyl phosphate AZD 3355 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Minocycline Dasatinib 4-[5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)urea 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One Inhibitor of P38 Kinase 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine 3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea 3-(Benzyloxy)Pyridin-2-Amine 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One 4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline Doramapimod 2-Chlorophenol 4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole SB220025 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE Triazolopyridine KC706 Talmapimod VX-702 R-1487 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide Neflamapimod N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide PH-797804 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine SD-0006 N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO- 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE Fostamatinib
Diseases		Osteosarcoma Adrenal carcinoma Thyroid cancer Breast cancer Basal cell carcinoma Malignant melanoma Pancreatic cancer Gastric cancer Malignant pleural mesothelioma Non-small cell lung cancer Esophageal cancer Oral cancer Multiple myeloma Small cell lung cancer Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL) Glioma Squamous cell carcinoma Kaposi's sarcoma Cholangiocarcinoma Gallbladder cancer Cancer of the anal canal Hepatocellular carcinoma Choriocarcinoma Vulvar cancer Choroid plexus papilloma Burkitt lymphoma Adult T-cell leukemia Hairy-cell leukemia Bladder cancer Chronic lymphocytic leukemia (CLL) Penile cancer Endometrial Cancer Ovarian cancer Colorectal cancer Laryngeal cancer Chronic myeloid leukemia (CML)
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887 21946351) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cancer ( 28346444) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure ( 28135244 27841878 30578418) Esophageal squamous cell carcinoma ( 25129146) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 29743610) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Nevus count or cutaneous melanoma ( 32341527) Non-glioblastoma glioma ( 28346443 29743610) Pulse pressure ( 28135244 27841878 30578418) Red blood cell count ( 32888494) Sex hormone levels ( 26014426) Sporadic neuroblastoma ( 28545128) Uterine fibroids ( 31249589 30194396 31649266)	Foot ulcer in diabetes and neuropathy ( 28672053)
Interacting Genes		489 interacting genes: ABL1 ACKR3 ACTA1 AGT AKAP5 AKT1 ANK2 ANKRD2 ANTKMT ANXA2 ANXA3 APBB2 APEX1 APOH APPL1 APTX ARAF ARID1A ARID3A ARIH2 ARL3 ARNT ASH2L ATF3 ATM ATR ATRX ATXN3 AURKA AXIN1 BAG5 BAG6 BAIAP2L1 BAK1 BANP BARD1 BAX BCCIP BCL2 BCL2L1 BCL2L12 BCL2L2 BCL6 BCR BLM BMP1 BRCA1 BRCA2 BRF1 BTBD2 BTK C10orf90 CABLES1 CABLES2 CAPG CAPN1 CARM1 CBLC CCDC106 CCL18 CCNA2 CCNG1 CCNH CCT5 CD40LG CDC14A CDC14B CDC25C CDC34 CDC42 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDKN1A CDKN2A CDKN2B CDKN2C CEBPZ CENPX CETP CHD3 CHEK1 CHEK2 CHUK COP1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 COX17 CR2 CRBN CREBBP CREBZF CRK CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CSNK2B CUL9 CXXC1 CYLD DAPK3 DAXX DCAF1 DDX20 DDX5 DGKZ DHCR24 DHFR DLEU1 DMTF1 DNAJB1 DNAJC7 DNMT3L DTL DVL2 E2F1 E4F1 EAF2 EEF2 EFEMP2 EGLN3 EGR1 EHMT1 EHMT2 EIF2AK2 EIF2S2 ELL ELL3 EP300 EPHA2 EPHA3 ERBB2 ERCC2 ERCC3 ERCC6 ERH ESR1 FBXO11 FBXO42 FBXW7 FCAMR FGFR4 FOS FOXO3 FXYD6 FZR1 GADD45A GNL3 GPS1 GPS2 GPX2 GRWD1 GSK3B GSTM4 GTF2H1 GTF2H4 GYS2 HABP4 HDAC1 HDAC2 HDAC3 HECTD3 HECW1 HEY1 HIF1A HINFP HIPK1 HIPK2 HMGA2 HMGB1 HMGB2 HNF4A HNRNPUL1 HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA9 HSPB1 HTT HUWE1 IFI16 IKBKB ING1 ING4 ING5 IRF7 ITPK1 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KAT7 KAT8 KDM1A KDM4D KIAA0087 KLF4 KLF6 KMT5A KPNA2 KPNA4 KPNB1 LACTB LAMA4 LAMTOR5 LATS2 LDB3 MAD2L1BP MAGEA2 MAGEB18 MAML1 MAP2K3 MAP2K5 MAP3K1 MAPK1 MAPK10 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MDC1 MDH1 MDM2 MDM4 MED1 MED17 MED21 MEN1 MET MIF MKRN2 MNAT1 MNDA MPHOSPH6 MSL2 MSX1 MTA1 MTA2 MUC1 MUL1 MVP MYBBP1A MYC NABP1 NABP2 NAP1L1 NAT10 NCL NCOA1 NCOA2 NCOA3 NDN NEDD8 NEIL3 NF2 NFKBIA NFYA NFYB NGFR NMT1 NMT2 NOP53 NPM1 NQO1 NR0B2 NR3C1 NR4A1 NTHL1 OTUB1 OTUD5 PADI1 PAFAH1B3 PARP1 PBK PCDHA4 PDGFRA PDLIM7 PELI1 PELI2 PELP1 PER2 PHB PIAS1 PIAS2 PIAS4 PIN1 PLAGL1 PLCG2 PLK1 PLK3 PML PNP POLA1 PPA1 PPARGC1A PPIB PPM1D PPP1CA PPP1CC PPP1R13L PPP2CA PPP2R2B PPP4C PRIM1 PRKAB2 PRKCA PRKD1 PRKDC PRKN PRKRA PRMT1 PRPF8 PSMB3 PSMC5 PSMD11 PSMD4 PSME3 PTEN PTGS2 PTK2 PTTG1 RAB4A RAB7A RAD51 RANBP9 RAP1B RB1 RBBP6 RBCK1 RBPJ RCHY1 RELA RING1 RNF125 RNF128 RNF38 RPA1 RPS6KA1 RPS6KA2 RPS6KA3 RRM2 RRM2B RUNX3 S100A2 S100A4 S100A6 S100A8 S100B SAT1 SCAMP1 SERPINB9 SETD7 SFN SHISA5 SIN3A SIN3B SIRT1 SLC9A9 SMAD2 SMAD3 SMARCA4 SMARCB1 SMARCD1 SMN1 SMYD2 SNRPN SP1 SP3 SRC SRSF1 SSTR3 STAMBP STARD10 STAT6 STK11 STK4 STX5 SUB1 SULT1E1 SUMO1 SYVN1 TADA3 TAF1 TAF1A TAF1B TAF1C TAF9 TAF9B TBP TCF4 TEAD2 TEC TEP1 TFAP2A TFAP2C TFDP1 TFIP11 THAP12 THAP8 THRB TIAF1 TK1 TOP1 TOP1MT TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TP53INP1 TP53RK TP63 TP73 TRIAP1 TRIM27 TRIM39 TRIM67 TSC22D1 TSG101 TTK TWIST1 TXN UBB UBE2A UBE2D1 UBE2D3 UBE2I UBE2K UBE2L3 UBE2M UBE2N UBE2Q1 UBE2V2 UBE3A UFD1 UHRF1 UHRF2 UIMC1 USP11 USP21 USP24 USP28 USP3 USP42 USP49 USP7 UTP14A VRK1 WDR33 WDR5 WDR82 WRN WT1 WWOX XAF1 XPO1 XRCC6 YBX1 YWHAG YWHAZ YY1 YY2 ZBTB2 ZBTB49 ZCCHC10 ZHX1 ZIC3 ZMIZ2 ZNF148 ZNF24 ZNF302 ZNF679 ZNF839 ZNHIT1	165 interacting genes: AIMP1 AKT1 ARNT ATF2 BCL2 BCL2L1 BICD1 BMI1 CCDC14 CCDC97 CCND2 CD4 CDC25A CDC25B CDC25C CDK4 CDK6 CDKN2A CDT1 CDX2 CENPC CEP164 COPS5 CREB1 CSNK2A1 CSNK2A2 CSNK2B DAB1 DDIT3 DUSP1 DUSP10 DUSP16 DUSP2 DUSP22 DUSP4 DUSP7 DUSP9 DYRK1B EEA1 EEF1A1 EEF2K EGFR EIF4EBP1 ELK1 ELK3 EPB42 EPHA2 EPS15 ESR1 ETV1 FGFR4 FKBP8 FLNA GADD45A GATA3 GDF15 GMFB GORASP2 GRB2 HDAC3 HIVEP1 HNF4A HSF4 HSPB1 HTRA2 ILKAP INTS6L IRAK1 JDP2 JUN JUNB KAT2A KAT2B KMT2C KRT18 KRT8 LATS2 LIMK1 MAFA MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K10 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MARS1 MAX MBP MEF2A MEF2C MEF2D MIDEAS MITF MKNK1 MKNK2 MOB3B MUC12 MYC NCOA3 NF2 NFATC1 NFATC4 NFIC NKTR NRL NUP153 PAK6 PHC2 PI4K2B PLA2G4A PLG PML PPARGC1A PPP4R3A PTPN7 RB1 RBSN RELA RET ROBO1 RPL22 RPL41 RPS6KA4 RPS6KA5 S100A9 SCN8A SH2D1A SHC1 SLC9A1 SMAD3 SMAD7 SMARCD3 SNAPIN SPAG9 SPTBN1 SQSTM1 SRPK1 SRSF5 STAT1 STAT4 STK11 STK39 SUPT20H TAB1 TCF20 TFCP2 TLE5 TMEM63B TP53 TRAF6 TSC1 UGT2B10 ULK1 YY1AP1 ZFP36L1 ZNF142 ZNHIT1
Entrez ID		7157	1432
HPRD ID		01859	02619
Ensembl ID		ENSG00000141510	ENSG00000112062
Uniprot IDs		A0A087WT22 A0A087WXZ1 A0A087X1Q1 H2EHT1 K7PPA8 P04637 Q53GA5	A0A024RD15 B4E0K5 L7RSM2 Q16539
PDB IDs		1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2FOJ 2FOO 2GS0 2H1L 2H2D 2H2F 2H4F 2H4H 2H4J 2H59 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2K8F 2L14 2LY4 2MEJ 2MWO 2MWP 2MWY 2MZD 2OCJ 2PCX 2RUK 2VUK 2WGX 2X0U 2X0V 2X0W 2XWR 2YBG 2YDR 2Z5S 2Z5T 3D05 3D06 3D07 3D08 3D09 3D0A 3DAB 3DAC 3IGK 3IGL 3KMD 3KZ8 3LW1 3OQ5 3PDH 3Q01 3Q05 3Q06 3SAK 3TG5 3TS8 3ZME 4AGL 4AGM 4AGN 4AGO 4AGP 4AGQ 4BUZ 4BV2 4HFZ 4HJE 4IBQ 4IBS 4IBT 4IBU 4IBV 4IBW 4IBY 4IBZ 4IJT 4KVP 4LO9 4LOE 4LOF 4MZI 4MZR 4QO1 4RP6 4RP7 4X34 4XR8 4ZZJ 5A7B 5AB9 5ABA 5AOI 5AOJ 5AOK 5AOL 5AOM 5BUA 5ECG 5G4M 5G4N 5G4O 5HOU 5HP0 5HPD 5LAP 5LGY 5MCT 5MCU 5MCV 5MCW 5MF7 5MG7 5MHC 5MOC 5O1A 5O1B 5O1C 5O1D 5O1E 5O1F 5O1G 5O1H 5O1I 5OL0 5UN8 5XZC 6FF9 6FJ5 6GGA 6GGB 6GGC 6GGD 6GGE 6GGF 6R5L 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RWH 6RWI 6RWS 6RWU 6RX2 6RZ3 6S39 6S3C 6S40 6S9Q 6SHZ 6SI0 6SI1 6SI2 6SI3 6SI4 6SIN 6SIO 6SIP 6SIQ 6SL6 6SLV 6T58 6V4F 6V4H 6VQO 6VR1 6VR5 6VRM 6VRN 7BWN	1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2FSL 2FSM 2FSO 2FST 2GFS 2I0H 2LGC 2NPQ 2OKR 2ONL 2QD9 2RG5 2RG6 2Y8O 2YIS 2YIW 2YIX 2ZAZ 2ZB0 2ZB1 3BV2 3BV3 3BX5 3C5U 3CTQ 3D7Z 3D83 3DS6 3DT1 3E92 3E93 3FC1 3FI4 3FKL 3FKN 3FKO 3FL4 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN 3FSF 3FSK 3GC7 3GCP 3GCQ 3GCS 3GCU 3GCV 3GFE 3GI3 3HA8 3HEC 3HEG 3HL7 3HLL 3HP2 3HP5 3HRB 3HUB 3HUC 3HV3 3HV4 3HV5 3HV6 3HV7 3HVC 3IPH 3ITZ 3IW5 3IW6 3IW7 3IW8 3K3I 3K3J 3KF7 3KQ7 3L8S 3L8X 3LFA 3LFB 3LFC 3LFD 3LFE 3LFF 3LHJ 3MGY 3MH0 3MH1 3MH2 3MH3 3MPA 3MPT 3MVL 3MVM 3MW1 3NEW 3NNU 3NNV 3NNW 3NNX 3NWW 3O8P 3O8T 3O8U 3OBG 3OBJ 3OC1 3OCG 3OD6 3ODY 3ODZ 3OEF 3PG3 3QUD 3QUE 3RIN 3ROC 3S3I 3S4Q 3U8W 3UVP 3UVQ 3UVR 3ZS5 3ZSG 3ZSH 3ZSI 3ZYA 4A9Y 4AA0 4AA4 4AA5 4AAC 4DLI 4DLJ 4E5A 4E5B 4E6A 4E6C 4E8A 4EH2 4EH3 4EH4 4EH5 4EH6 4EH7 4EH8 4EH9 4EHV 4EWQ 4F9W 4F9Y 4FA2 4GEO 4KIN 4KIP 4KIQ 4L8M 4R3C 4ZTH 5ETA 5ETC 5ETF 5ETI 5ML5 5MTX 5MTY 5MZ3 5N63 5N64 5N65 5N66 5N67 5N68 5O8U 5O8V 5OMG 5OMH 5TBE 5TCO 5WJJ 5XYX 5XYY 6ANL 6HWT 6HWU 6HWV 6M95 6M9L 6OHD 6QDZ 6QE1 6QYX 6RFO 6SFI 6SFJ 6SFK 6SFO 6TCA 6ZWP
Enriched GO Terms of Interacting Partners?
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