BTK and PIP4K2B

Data Source:
HPRD (in vitro, in vivo)

		BTK	PIP4K2B
Description		Bruton tyrosine kinase	phosphatidylinositol-5-phosphate 4-kinase type 2 beta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding	Protein Binding ATP Binding GTP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Cytokine Production Adaptive Immune Response B Cell Affinity Maturation Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Negative Regulation Of B Cell Proliferation Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Innate Immune Response Positive Regulation Of B Cell Differentiation Protein Autophosphorylation Cell Maturation B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway Cellular Response To Interleukin-7	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Autophagosome-lysosome Fusion Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs		Dasatinib Inositol 1,3,4,5-Tetrakisphosphate XL418 Ibrutinib Acalabrutinib Fostamatinib Zanubrutinib Abivertinib	Fostamatinib
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8 Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Height ( 28552196 20881960 31562340)
Interacting Genes		76 interacting genes: ABL1 APP AR ARHGAP17 ARID3A ARRB1 AURKA BCL2L11 BECN1 BLNK BMX CAV1 CBL CD19 CMTM3 COASY DAPP1 ERBB3 EWSR1 FAS FASLG FYN GAB1 GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MDM2 MEOX2 MET MRPS22 MYD88 PIK3AP1 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 SMURF1 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2	17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131
Entrez ID		695	8396
HPRD ID		02248	04463
Ensembl ID		ENSG00000010671	ENSG00000276293
Uniprot IDs		Q06187 Q5JY90	P78356
PDB IDs		1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 4NWM 4OT5 4OT6 4OTF 4OTQ 4OTR 4RFY 4RFZ 4RG0 4RX5 4YHF 4Z3V 4ZLY 4ZLZ 5BPY 5BQ0 5FBN 5FBO 5J87 5JRS 5KUP 5P9F 5P9G 5P9H 5P9I 5P9J 5P9K 5P9L 5P9M 5T18 5U9D 5VFI 5VGO 5XYZ 5ZZ4 6AUA 6AUB 6BIK 6BKE 6BKH 6BKW 6BLN 6DI0 6DI1 6DI3 6DI5 6DI9 6E4F 6EP9 6HRP 6HRT 6HTF 6J6M 6N9P 6NFH 6NFI 6NZM 6O8I 6OMU 6S90 6TFP 6X3N 6X3O 6X3P 6XE4	1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H
Enriched GO Terms of Interacting Partners?
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