RRM2 and ST3GAL3

Data Source:
BioGRID (two hybrid)

		RRM2	ST3GAL3
Description		ribonucleotide reductase regulatory subunit M2	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding	Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Negative Regulation Of G0 To G1 Transition	Protein Glycosylation O-glycan Processing Keratan Sulfate Biosynthetic Process Sialylation
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256)
Interacting Genes		9 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B SDCBP TP53	5 interacting genes: ACTG1 RPL8 SCAMP2 TTR ZBTB5
Entrez ID		6241	6487
HPRD ID		01587	05930
Ensembl ID		ENSG00000171848	ENSG00000126091
Uniprot IDs		P31350	A0A2R8Y732 Q11203
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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