RRM1 and LRIF1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RRM1	LRIF1
Description		ribonucleotide reductase catalytic subunit M1	ligand dependent nuclear receptor interacting factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body	Chromosome, Telomeric Region Barr Body Nucleoplasm Nuclear Matrix Centriolar Satellite
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Protein Binding Retinoic Acid Receptor Binding
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye	Regulation Of Transcription, DNA-templated Dosage Compensation By Inactivation Of X Chromosome
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)	Bone mineral content ( 31790847) Intraocular pressure ( 30591961)
Interacting Genes		10 interacting genes: BMI1 CDC42 LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655	144 interacting genes: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BANP BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX3 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRACR2A CRADD CRCP CRCT1 DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FHL2 FOSL2 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 H3-4 HAP1 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NOC2L NR3C1 NRBP1 NTAQ1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR1C POLR2C POLR3F PPARG PQBP1 PRKAB2 PRKAR2A PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SNU13 SPATA18 SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TDGF1 TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSEN15 TSPAN6 UBE2V2 UNC119 VIM VPS26C WDR62 WWC1 ZNF24 ZNF410
Entrez ID		6240	55791
HPRD ID		01588	17975
Ensembl ID		ENSG00000167325	ENSG00000121931
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	Q5T3J3
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L
Enriched GO Terms of Interacting Partners?
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