POLE4 and REG3G

Data Source:
BioGRID (biochemical)

		POLE4	REG3G
Description		DNA polymerase epsilon 4, accessory subunit	regenerating family member 3 gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	Signaling Receptor Activity Peptidoglycan Binding Oligosaccharide Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	MyD88-dependent Toll-like Receptor Signaling Pathway Acute-phase Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Antimicrobial Humoral Response Response To Peptide Hormone Cell Wall Disruption In Other Organism Negative Regulation Of Keratinocyte Differentiation Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Antimicrobial peptides
Drugs		Cladribine
Diseases
GWAS			Acute insulin response ( 28490609) Blood protein levels ( 30072576) Body mass index ( 26426971) Contrast sensitivity ( 24152035) Metabolite levels ( 31628463)
Interacting Genes		7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A
Entrez ID		56655	130120
HPRD ID		16238	10137
Ensembl ID		ENSG00000115350	ENSG00000143954
Uniprot IDs		Q9NR33	Q6UW15
PDB IDs
Enriched GO Terms of Interacting Partners?
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