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THAP1 and U2AF2
Data Source:
BioGRID
(two hybrid, two hybrid)
HPRD
(two hybrid)
THAP1
U2AF2
Description
THAP domain containing 1
U2 small nuclear RNA auxiliary factor 2
Image
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
PML Body
Intracellular Membrane-bounded Organelle
Commitment Complex
Prp19 Complex
Nucleus
Nucleoplasm
Spliceosomal Complex
Nuclear Speck
U2-type Prespliceosome
U2AF Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
RNA Binding
Protein Binding
Poly-pyrimidine Tract Binding
Enzyme Binding
Pre-mRNA 3'-splice Site Binding
C2H2 Zinc Finger Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Endothelial Cell Proliferation
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cell Cycle
Regulation Of Mitotic Cell Cycle
MRNA Splicing, Via Spliceosome
MRNA Processing
RNA Export From Nucleus
MRNA Export From Nucleus
MRNA 3'-end Processing
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of RNA Splicing
Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Drugs
Diseases
Primary torsion dystonia (PTD)
GWAS
Pelvic organ prolapse (moderate/severe) (
26545240
)
HDL cholesterol levels (
32203549
)
Menopause (age at onset) (
26414677
)
Interacting Genes
105 interacting genes:
ABCF3
ACOT7
AEBP2
AKAP17A
AKAP9
AP2B1
APP
ARL6IP4
BAG5
BEND7
BMS1P1
BYSL
C1orf216
C1orf35
C4orf45
C7orf50
CDC37
CDKN2D
CHD2
CSNK2A1
DCAF8
DVL2
EEF1AKNMT
FAM124A
FAM133A
FAM9A
FGF10
FGF11
FGF12
FXR2
GAS8
GPATCH2L
HNRNPLL
HYPK
INO80B
KANK2
KLF12
KRTAP10-7
L3MBTL2
LASP1
LMNB2
LMO3
LNX1
MFAP1
MIS18A
MORF4L1
MORF4L2
MRPL11
MRPL53
NDUFAB1
NKAP
NKAPD1
NTAQ1
NUP62
PAWR
PHF1
PHF19
PID1
PNKP
POLR2L
POLR2M
POU6F2
PPIG
PRKAA1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QKI
RAD54L2
RALY
RALYL
RBM10
RBM39
RIPPLY1
RNF4
RP9P
RPL22
RPS25
SAP30BP
SERF2
SLU7
SPANXN2
SREK1IP1
STRBP
TCEA2
TCEANC
TPM3
TRAF5
TRIM26
TRIP10
TTLL10
TXN2
U2AF2
UBE2I
VCX2
WT1
YES1
ZBTB48
ZCCHC10
ZGPAT
ZNF385C
ZNF408
ZNF526
75 interacting genes:
APBB1
ATXN1
BEND7
CCAR1
CDC42
CHERP
CHIC2
CPSF7
DACH1
DDX39B
DDX6
DPPA2
DVL2
EPB41
FUBP1
GEMIN2
GLIS2
HLA-DMA
HMBOX1
IL7R
INO80B
KHDC4
KHDRBS3
LURAP1
MAP1B
MRPL15
NKAPD1
OTUB2
PHF5A
PIN1
POLR2A
PRPF3
PRPF40A
PUF60
QKI
RBFOX2
RBM11
RBM39
RBM4
RBMY1F
RBMY1J
SAP30BP
SCAF11
SF1
SF3B1
SF3B2
SF3B3
SF3B4
SF3B5
SF3B6
SMAD5
SNRPA
SRPK1
SRPK2
SRSF1
SRSF11
SRSF3
STAC3
SUGP1
SUMO2
TCERG1
TCF23
THAP1
TLE5
TOP1
U2AF1
U2AF1L5
WT1
ZNF107
ZNF526
ZNF57
ZNF71
ZNF835
ZRSR2
ZRSR2P1
Entrez ID
55145
11338
HPRD ID
15496
01872
Ensembl ID
ENSG00000131931
ENSG00000063244
Uniprot IDs
Q9NVV9
P26368
PDB IDs
2JTG
2KO0
2L1G
1JMT
1O0P
1OPI
1U2F
2G4B
2HZC
2M0G
2U2F
2YH0
2YH1
3VAF
3VAG
3VAH
3VAI
3VAJ
3VAK
3VAL
3VAM
4FXW
4TU7
4TU8
4TU9
5EV1
5EV2
5EV3
5EV4
5W0G
5W0H
6TR0
6XLV
6XLW
6XLX
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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