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THAP1 and CDC37
Data Source:
BioGRID
(two hybrid)
THAP1
CDC37
Description
THAP domain containing 1
cell division cycle 37, HSP90 cochaperone
Image
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
PML Body
Intracellular Membrane-bounded Organelle
Cytoplasm
Cytosol
Extracellular Exosome
Chaperone Complex
HSP90-CDC37 Chaperone Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Protein Binding
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
Heat Shock Protein Binding
Unfolded Protein Binding
Chaperone Binding
Hsp90 Protein Binding
Scaffold Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Endothelial Cell Proliferation
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Folding
Protein Targeting
Posttranscriptional Regulation Of Gene Expression
ERBB2 Signaling Pathway
Protein Stabilization
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Pathways
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by EGFRvIII
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
RHOBTB2 GTPase cycle
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
Primary torsion dystonia (PTD)
GWAS
Pelvic organ prolapse (moderate/severe) (
26545240
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Multiple sclerosis (
21833088
)
White blood cell count (
32888494
)
Interacting Genes
105 interacting genes:
ABCF3
ACOT7
AEBP2
AKAP17A
AKAP9
AP2B1
APP
ARL6IP4
BAG5
BEND7
BMS1P1
BYSL
C1orf216
C1orf35
C4orf45
C7orf50
CDC37
CDKN2D
CHD2
CSNK2A1
DCAF8
DVL2
EEF1AKNMT
FAM124A
FAM133A
FAM9A
FGF10
FGF11
FGF12
FXR2
GAS8
GPATCH2L
HNRNPLL
HYPK
INO80B
KANK2
KLF12
KRTAP10-7
L3MBTL2
LASP1
LMNB2
LMO3
LNX1
MFAP1
MIS18A
MORF4L1
MORF4L2
MRPL11
MRPL53
NDUFAB1
NKAP
NKAPD1
NTAQ1
NUP62
PAWR
PHF1
PHF19
PID1
PNKP
POLR2L
POLR2M
POU6F2
PPIG
PRKAA1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QKI
RAD54L2
RALY
RALYL
RBM10
RBM39
RIPPLY1
RNF4
RP9P
RPL22
RPS25
SAP30BP
SERF2
SLU7
SPANXN2
SREK1IP1
STRBP
TCEA2
TCEANC
TPM3
TRAF5
TRIM26
TRIP10
TTLL10
TXN2
U2AF2
UBE2I
VCX2
WT1
YES1
ZBTB48
ZCCHC10
ZGPAT
ZNF385C
ZNF408
ZNF526
178 interacting genes:
A2M
ACTB
ACTG1
AKT1
AMOTL2
APOE
APP
AR
BEND7
BHLHB9
BLZF1
BTBD10
BTBD3
C19orf44
CAMK2A
CAMK2B
CAMK2G
CARD10
CARD9
CAVIN1
CBY2
CC2D1A
CCDC138
CCDC152
CCDC91
CCHCR1
CDC37L1
CDK2
CDK3
CDK4
CDK5
CDK6
CDK7
CEP55
CEP70
CGGBP1
CHGA
CHUK
CKS1B
CKS2
CRYM
CSNK2A1
CSNK2A2
CT45A1
CTAG1A
CTAG1B
CUTC
CYP2C9
DCTN1
DEAF1
DISC1
ECSIT
EIF2AK1
EIF2S1
ELAVL3
ENOX2
EXOSC1
FAM118A
FAM9B
FATE1
FBXL12
FBXW4
GAS7
GAS8
GCDH
GCH1
GFAP
GMCL1
GOLGA2
GOLGA6L9
GRAMD2B
GRIPAP1
HIVEP1
HOMER3
HSF2BP
HSP90AA1
IFIT5
IKBKB
IKBKE
IKBKG
IKZF3
IMMT
JRK
KATNBL1
KCTD13
KCTD9
KIFC3
KLHL2
KRT75
KRT76
LMNB2
LONP1
LOXL4
LUC7L2
LZTS1
MAD1L1
MAP3K14
MAP3K3
MDFI
MID1
MIPOL1
MRPL9
MTOR
MZT2B
NCOA5
NECAB1
NECAB2
NOS3
NR2C2
NRIP3
NT5C1A
OGA
PAICS
PDE9A
PIBF1
PNMA2
POU6F2
PPHLN1
PPP5C
PRAM1
PRDX2
PRKAR1B
PRMT1
PRMT5
PRPH
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMC6
PSME1
PTGES3
RABGEF1
RAD23A
RAF1
REEP6
RNF32
ROPN1
RPS15A
SAFB
SEPTIN3
SNX5
SPTBN4
SQSTM1
SRC
SRRM4
SSNA1
STAMBPL1
STIP1
STK11
STK32A
STX1A
SYCE2
SYCP3
TBK1
TCF4
THAP1
THAP7
TNFAIP1
TNIP1
TRAF2
TRAF3
TRAF5
TRIM54
UBE2I
USHBP1
WAC
ZBED1
ZBTB26
ZBTB8A
ZNF205
ZNF235
ZNF266
ZNF276
ZNF655
ZNF667
ZNF837
Entrez ID
55145
11140
HPRD ID
15496
05456
Ensembl ID
ENSG00000131931
ENSG00000105401
Uniprot IDs
Q9NVV9
A0A024R7B7
Q16543
PDB IDs
2JTG
2KO0
2L1G
1US7
2K5B
2N5X
2NCA
2W0G
5FWK
5FWL
5FWM
5FWP
5HPE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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