POLE3 and ALAD

Data Source:
BioGRID (two hybrid)

		POLE3	ALAD
Description		DNA polymerase epsilon 3, accessory subunit	aminolevulinate dehydratase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex CHRAC	Extracellular Region Nucleus Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	Catalytic Activity Porphobilinogen Synthase Activity Zinc Ion Binding Identical Protein Binding Proteasome Core Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Telomere Maintenance Via Semi-conservative Replication Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Response To Oxidative Stress Response To Herbicide Response To Iron Ion Response To Zinc Ion Response To Aluminum Ion Response To Ionizing Radiation Response To Vitamin B1 Response To Selenium Ion Response To Activity Response To Cobalt Ion Response To Lipopolysaccharide Response To Vitamin E Response To Drug Response To Amino Acid Neutrophil Degranulation Response To Ethanol Response To Arsenic-containing Substance Response To Cadmium Ion Response To Mercury Ion Protein Homooligomerization Response To Glucocorticoid Response To Methylmercury Response To Platinum Ion Response To Fatty Acid Cellular Response To Lead Ion Cellular Response To Interleukin-4 Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Heme biosynthesis Neutrophil degranulation
Drugs		Cladribine	Aminolevulinic acid Delta-Amino Valeric Acid Laevulinic Acid 4-Oxosebacic Acid Porphobilinogen 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid 4,7-Dioxosebacic Acid 5-hydroxyvaleric acid
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lead levels in blood ( 25820613) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		7 interacting genes: APP BAZ1A CHRAC1 DR1 DRAP1 POLE4 SMARCA5
Entrez ID		54107	210
HPRD ID		06274	00504
Ensembl ID		ENSG00000148229	ENSG00000148218
Uniprot IDs		A0A024R829 Q9NRF9	A0A024R877 A0A140VJL9 B7Z3I9 P13716 Q6ZMU0
PDB IDs			1E51 1PV8 5HMS 5HNR
Enriched GO Terms of Interacting Partners?
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