PDCD1 and COPS8

Data Source:
BioGRID (affinity chromatography technology)

		PDCD1	COPS8
Description		programmed cell death 1	COP9 signalosome subunit 8
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Apoptotic Process Humoral Immune Response Multicellular Organism Development T Cell Costimulation Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of T Cell Apoptotic Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Post-translational Protein Modification
Pathways		PD-1 signaling Potential therapeutics for SARS	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs		CT-011 Nivolumab Pembrolizumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680
Diseases		Systemic lupus erythematosus
GWAS		Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)	Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)
Interacting Genes		2 interacting genes: CD274 PDCD1LG2	17 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA SUOX TP53 USHBP1
Entrez ID		5133	10920
HPRD ID		02590	16737
Ensembl ID		ENSG00000188389	ENSG00000198612
Uniprot IDs		A0A0M3M0G7 Q15116	A0A024R4D1 Q99627
PDB IDs		2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CU5	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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