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MSH3 and MSH2
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
MSH3
MSH2
Description
mutS homolog 3
mutS homolog 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
Mismatch Repair Complex
MutSbeta Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Membrane
Mismatch Repair Complex
MutSalpha Complex
MutSbeta Complex
Molecular Function
Single-stranded DNA Binding
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
Enzyme Binding
Mismatched DNA Binding
DNA Insertion Or Deletion Binding
Guanine/thymine Mispair Binding
Dinucleotide Insertion Or Deletion Binding
Single Guanine Insertion Binding
Dinucleotide Repeat Insertion Binding
Oxidized Purine DNA Binding
Protein Homodimerization Activity
Magnesium Ion Binding
Four-way Junction DNA Binding
Double-strand/single-strand DNA Junction Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
ATPase Activity
Centromeric DNA Binding
Enzyme Binding
Protein Kinase Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Dinucleotide Insertion Or Deletion Binding
Single Guanine Insertion Binding
Single Thymine Insertion Binding
Dinucleotide Repeat Insertion Binding
Oxidized Purine DNA Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
ADP Binding
Biological Process
Meiotic Mismatch Repair
Removal Of Nonhomologous Ends
DNA Repair
Mismatch Repair
Mitotic Recombination
Reciprocal Meiotic Recombination
Somatic Recombination Of Immunoglobulin Gene Segments
Replication Fork Arrest
Maintenance Of DNA Repeat Elements
Negative Regulation Of DNA Recombination
Positive Regulation Of Helicase Activity
In Utero Embryonic Development
Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response
Oxidative Phosphorylation
DNA Repair
Mismatch Repair
Postreplication Repair
Double-strand Break Repair
DNA Recombination
Cell Cycle Arrest
Germ Cell Development
Determination Of Adult Lifespan
Male Gonad Development
Response To X-ray
Response To UV-B
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
B Cell Mediated Immunity
B Cell Differentiation
Intra-S DNA Damage Checkpoint
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Neuron Apoptotic Process
Maintenance Of DNA Repeat Elements
Isotype Switching
Negative Regulation Of DNA Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Positive Regulation Of Helicase Activity
Protein Localization To Chromatin
Pathways
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH2
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
Colorectal cancer
Colorectal cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Ovarian cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Huntington's disease progression (
28642124
)
Idiopathic downbeat nystagmus (
32157568
)
Subcortical volume (MOSTest) (
32665545
)
Electroencephalogram traits (
25387704
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
14 interacting genes:
BARD1
BRCA1
EXO1
HUS1
MLH1
MSH2
PCNA
RAD1
RAD9A
RCHY1
RPA4
SUMO2
TSC22D2
XPA
48 interacting genes:
AKT1
ANXA7
APPBP2
ATR
BARD1
BRCA1
CCDC180
CDC14B
CDC42
CDKN1A
CHEK2
CREBBP
DVL1
EPHA2
ESR1
ESR2
EXO1
FBP1
FBP2
FGFR4
GALNT12
GRB7
HDAC6
HRAS
HUS1
LEF1
MAX
MSH3
MSH6
MYC
PCNA
PPP3R2
RAD1
RAD9A
RPA4
RPP14
SMAD1
SMC1A
SMN1
STX17
SUMO2
TDRD7
TK1
TREX1
TRIM29
USP10
XPA
ZNF510
Entrez ID
4437
4436
HPRD ID
02931
00389
Ensembl ID
ENSG00000113318
ENSG00000095002
Uniprot IDs
P20585
A0A2R8Y6P0
P43246
PDB IDs
3THW
3THX
3THY
3THZ
2O8B
2O8C
2O8D
2O8E
2O8F
3THW
3THX
3THY
3THZ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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