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KMT2A and EXOSC5
Data Source:
HPRD
(in vivo, in vitro)
KMT2A
EXOSC5
Description
lysine methyltransferase 2A
exosome component 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Histone Methyltransferase Complex
MLL1 Complex
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
Minor Groove Of Adenine-thymine-rich DNA Binding
Protein Binding
Zinc Ion Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Identical Protein Binding
Protein Homodimerization Activity
Unmethylated CpG Binding
Lysine-acetylated Histone Binding
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Apoptotic Process
Positive Regulation Of Transporter Activity
Circadian Regulation Of Gene Expression
Embryonic Hemopoiesis
Histone H4-K16 Acetylation
Histone H3-K4 Dimethylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K4 Methylation
Protein-containing Complex Assembly
Regulation Of Histone H3-K14 Acetylation
Histone H3-K4 Trimethylation
Histone H3-K4 Monomethylation
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of DNA Methylation
Regulation Of Histone H3-K9 Acetylation
RRNA Processing
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Polyadenylation-dependent SnoRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Metabolic syndrome (
31589552
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Interacting Genes
31 interacting genes:
ASH2L
AVP
BMI1
CBX4
CREBBP
CTNNB1
FASLG
H3-3A
H3-4
H3C1
H3C14
HCFC1
HCFC2
INS
KAT8
MEN1
MTM1
OXT
PAF1
PLXNB1
PPIE
PPP1R15A
RBBP5
RNF2
SBF1
SET
SVIL
TAF9
TASP1
TOP1
WDR5
80 interacting genes:
ACOT11
ADAMTSL4
BIRC2
BORCS6
CALCOCO2
CCDC88B
CDK5RAP1
DAAM2
DDIT4L
DHRS2
DIS3
DMRTB1
DOCK8
EFHC2
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FCHO1
FH
FHL3
GOLGA2
HBS1L
HOXC4
IKZF3
KCTD13
KIAA1217
KRT13
KRT27
KRT31
KRT34
KRT35
LCA5L
LIPG
LRMDA
LSM3
LSM5
LZTS2
MEOX2
MPHOSPH6
MTMR3
MTREX
MYLIP
NKAPD1
NMI
NUP210
PA2G4
PALS2
PEG10
PICK1
PIH1D2
PKM
POLR2L
PRDM6
PTEN
REL
SFPQ
SH3GLB1
SH3GLB2
SHISA6
SNW1
SPTA1
TEX11
TFIP11
TLE5
TNFAIP1
TRIB3
TRIM54
TRIM62
ZFP90
ZMAT1
ZNF420
ZNF558
ZNF620
ZNF655
ZNF792
Entrez ID
4297
56915
HPRD ID
01162
16222
Ensembl ID
ENSG00000118058
ENSG00000077348
Uniprot IDs
Q03164
Q9NQT4
PDB IDs
2AGH
2J2S
2JYI
2KKF
2KU7
2KYU
2LXS
2LXT
2MSR
2MTN
2W5Y
2W5Z
3EG6
3EMH
3LQH
3LQI
3LQJ
3P4F
3U85
3U88
4ESG
4GQ6
4NW3
5F5E
5F6L
5SVH
6EMQ
6KIU
6KIV
6KIX
6KIZ
6PWV
6PWW
6U9K
6U9M
6U9N
6U9R
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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