IL6ST and LIF

Data Source:
HPRD (in vivo)

		IL6ST	LIF
Description		interleukin 6 cytokine family signal transducer	LIF interleukin 6 family cytokine
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Identical Protein Binding Interleukin-27 Receptor Activity	Signaling Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway	Blood Vessel Remodeling Immune Response Tyrosine Phosphorylation Of STAT Protein Multicellular Organism Development Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Regulation Of Cell Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Hormone Secretion Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Histone H3-K27 Acetylation Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Rheumatoid arthritis ( 20453842)	Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Nephropathy ( 21399633) Tonsillectomy ( 27941131)
Interacting Genes		34 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1	6 interacting genes: HPGDS IL6ST KRT31 KRTAP12-3 LIFR NCALD
Entrez ID		3572	3976
HPRD ID		02824	08869
Ensembl ID		ENSG00000134352	ENSG00000128342
Uniprot IDs		A0A0A0N0L2 P40189 Q17RA0	P15018
PDB IDs		1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J	1EMR 1PVH 2Q7N
Enriched GO Terms of Interacting Partners?
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