IHO1 and ADAMTS12

Data Source:
BioGRID (two hybrid)

		IHO1	ADAMTS12
Description		interactor of HORMAD1 1	ADAM metallopeptidase with thrombospondin type 1 motif 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome	Extracellular Matrix
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	DNA Recombination Homologous Chromosome Pairing At Meiosis Spermatogenesis Meiotic DNA Double-strand Break Formation Oogenesis Regulation Of Homologous Chromosome Segregation	Cell-matrix Adhesion Cell Migration Proteoglycan Catabolic Process Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To BMP Stimulus Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus
Pathways			Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825) Height ( 31217584) Metabolite levels ( 23823483) Mortality in heart failure ( 20400778) Neurofibrillary tangles ( 31497858) Seasonality and depression ( 30217971) Stroke (pediatric) ( 22990015)
Interacting Genes		78 interacting genes: ABI2 ABI3 ADAMTS12 AQP1 ARHGEF9 ATP6V0D1 BCL6 BOLA2 BOLA2B C1orf109 CARD9 CCDC120 CCDC57 CDC23 CFAP206 COX5B DGCR6 DVL2 DYNLL1 DYNLL2 EAF2 EFHC1 EXOC8 FAM124A FAM124B FANCG FANCL FASLG FHL3 FKBP6 GEM GLRX3 GLYCTK GOLGA2 GRAP2 GYS1 HEXIM2 HINFP IQUB KANK2 KIF9 KIFC3 KLC3 KLHL11 LMO2 LNX1 LONRF1 MAGEB4 MAGOHB MAPK9 MID2 MRFAP1L1 MVP MYO15B NEK6 NFKBID NGB PICK1 POLR1C PRKAB2 PRR34 RABGEF1 RAD51D RHOBTB3 RUNX1T1 SDCBP SMARCB1 STK25 TNS2 TRIM14 TRIM42 TTC19 USP2 USP20 ZGPAT ZKSCAN3 ZNF417 ZNF688	7 interacting genes: CALM2 COIL IHO1 MEOX2 MYL6 TP53BP2 TRIM14
Entrez ID		339834	81792
HPRD ID		14172	05862
Ensembl ID		ENSG00000173421	ENSG00000151388
Uniprot IDs		B4DZP6 Q8IYA8	D6REX0 P58397
PDB IDs
Enriched GO Terms of Interacting Partners?
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