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IHO1 and FASLG
Data Source:
BioGRID
(two hybrid)
IHO1
FASLG
Description
interactor of HORMAD1 1
Fas ligand
Image
No pdb structure
GO Annotations
Cellular Component
Condensed Nuclear Chromosome
Extracellular Region
Extracellular Space
Nucleus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Cytoplasmic Vesicle Lumen
Extracellular Exosome
Molecular Function
Protein Binding
Signaling Receptor Binding
Death Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Biological Process
DNA Recombination
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Meiotic DNA Double-strand Break Formation
Oogenesis
Regulation Of Homologous Chromosome Segregation
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Cell Apoptotic Process
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Cellular Chloride Ion Homeostasis
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Retinal Cell Programmed Cell Death
Endosomal Lumen Acidification
T Cell Apoptotic Process
Necroptotic Process
Response To Growth Factor
Cellular Response To Interferon-gamma
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum
Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Interleukin-4 and Interleukin-13 signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
FOXO-mediated transcription of cell death genes
TNFs bind their physiological receptors
Drugs
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic sensitization (
30013184
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
24999842
)
Crohn's disease (
21102463
23128233
)
Daytime sleep phenotypes (
27126917
)
Itch intensity from mosquito bite (
28199695
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
28714469
)
Vitiligo (
27723757
)
Interacting Genes
78 interacting genes:
ABI2
ABI3
ADAMTS12
AQP1
ARHGEF9
ATP6V0D1
BCL6
BOLA2
BOLA2B
C1orf109
CARD9
CCDC120
CCDC57
CDC23
CFAP206
COX5B
DGCR6
DVL2
DYNLL1
DYNLL2
EAF2
EFHC1
EXOC8
FAM124A
FAM124B
FANCG
FANCL
FASLG
FHL3
FKBP6
GEM
GLRX3
GLYCTK
GOLGA2
GRAP2
GYS1
HEXIM2
HINFP
IQUB
KANK2
KIF9
KIFC3
KLC3
KLHL11
LMO2
LNX1
LONRF1
MAGEB4
MAGOHB
MAPK9
MID2
MRFAP1L1
MVP
MYO15B
NEK6
NFKBID
NGB
PICK1
POLR1C
PRKAB2
PRR34
RABGEF1
RAD51D
RHOBTB3
RUNX1T1
SDCBP
SMARCB1
STK25
TNS2
TRIM14
TRIM42
TTC19
USP2
USP20
ZGPAT
ZKSCAN3
ZNF417
ZNF688
82 interacting genes:
APBB1
ARHGAP9
BAIAP2L1
BTK
CACNB3
CACNB4
CRK
CYSRT1
DAXX
DLG2
DMD
DNMBP
DOCK4
ECM1
EPS8L3
EZR
FADD
FAS
FGR
FN1
FNBP1
FYB1
FYN
GRAP
GRAP2
GRB2
HCK
IHO1
ITK
ITSN2
KALRN
KMT2A
KRT33B
KRT40
KRTAP11-1
KRTAP12-3
LCK
LYN
MACC1
MIA
MMP7
MPP4
MYO15A
NCF1
NCK1
NCK2
NCKIPSD
NOTCH2NLA
OSTF1
PACSIN2
PDCD6
PIK3CA
PIK3R1
PIN1
PPIAP11
PRPF40A
PSTPIP1
PTPN13
RGS20
RIMBP3C
SAMSN1
SEC23A
SH3GL3
SH3PXD2A
SH3PXD2B
SH3RF2
SKAP2
SNX33
SNX9
SORBS3
SPTA1
SRC
SRGAP1
SRGAP2
SRGAP3
SUMO1
TEC
TJP3
TNFRSF6B
TNS2
TRIP6
YES1
Entrez ID
339834
356
HPRD ID
14172
00610
Ensembl ID
ENSG00000173421
ENSG00000117560
Uniprot IDs
B4DZP6
Q8IYA8
P48023
Q53ZZ1
PDB IDs
1BZI
4MSV
5L19
5L36
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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