HSP90AB1 and CCR7

Data Source:
BioGRID (affinity chromatography technology)

		HSP90AB1	CCR7
Description		heat shock protein 90 alpha family class B member 1	C-C motif chemokine receptor 7
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane COP9 Signalosome Membrane Inclusion Body Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Protein-containing Complex Aryl Hydrocarbon Receptor Complex Secretory Granule Lumen Melanosome Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen HSP90-CDC37 Chaperone Complex Sperm Head Plasma Membrane Ooplasm	Mitochondrion Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	UTP Binding CTP Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding GTP Binding Drug Binding Sulfonylurea Receptor Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding DATP Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding ATP-dependent Protein Binding Protein Folding Chaperone Ion Channel Binding Cadherin Binding Protein Dimerization Activity Tau Protein Binding Unfolded Protein Binding DNA Polymerase Binding Disordered Domain Specific Binding Histone Methyltransferase Binding	G Protein-coupled Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 19 Binding Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 19 Receptor Activity C-C Motif Chemokine 21 Receptor Activity
	Biological Process	Placenta Development Protein Folding Xenobiotic Metabolic Process Response To Unfolded Protein Telomere Maintenance Via Telomerase Response To Salt Stress Virion Attachment To Host Cell Central Nervous System Neuron Axonogenesis Establishment Of Cell Polarity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To Drug Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Cocaine Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Size Axon Extension Protein Stabilization Chaperone-mediated Protein Complex Assembly Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Cell Cycle Arrest Cellular Response To Interleukin-4 Cellular Response To Organic Cyclic Compound Positive Regulation Of Protein Serine/threonine Kinase Activity Supramolecular Fiber Organization Regulation Of Cellular Response To Heat Negative Regulation Of Transforming Growth Factor Beta Activation Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Tau-protein Kinase Activity Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Cellular Protein Localization Positive Regulation Of Cyclin-dependent Protein Kinase Activity Telomerase Holoenzyme Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Establishment Of T Cell Polarity Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Hypersensitivity Positive Regulation Of Humoral Immune Response Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Ruffle Organization Response To Lipopolysaccharide Regulation Of Interferon-gamma Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-12 Production Response To Prostaglandin E Chemokine (C-C Motif) Ligand 19 Signaling Pathway Chemokine (C-C Motif) Ligand 21 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Thymic T Cell Selection Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Homeostasis Of Number Of Cells Positive Regulation Of T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Activation Of GTPase Activity Lymphocyte Migration Into Lymph Node Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Immunological Synapse Formation Positive Regulation Of T Cell Costimulation Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Regulation of actin dynamics for phagocytic cup formation HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase HSF1-dependent transactivation Sema3A PAK dependent Axon repulsion Uptake and function of diphtheria toxin Neutrophil degranulation The NLRP3 inflammasome The role of GTSE1 in G2/M progression after G2 checkpoint Aryl hydrocarbon receptor signalling ESR-mediated signaling RHOBTB2 GTPase cycle Estrogen-dependent gene expression Chaperone Mediated Autophagy Purinergic signaling in leishmaniasis infection Potential therapeutics for SARS	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Radicicol Tanespimycin SNX-5422 CCT-018159 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Polaprezinc
Diseases
GWAS		Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31959851 30929738) Asthma (childhood onset) ( 30929738) Eczema ( 31361310) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Type 1 diabetes ( 25751624)
Interacting Genes		59 interacting genes: ACD AKT1 ARHGAP1 CCT2 CDC37L1 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 EGFR ENO1 ESR1 ESRRB FCHSD2 GABARAPL1 GABARAPL2 HSF1 HSPB1 IKBKB IKBKE IKBKG ITGB1BP2 KEAP1 MAP3K14 MAP3K3 MAPK6 MAST1 MKNK1 NR2C2 NR3C1 NR4A1 POT1 PPID PTEN PTGES3 RHOBTB2 SERPINB5 SGTA SIRPA SLC34A1 STARD13 STAT1 STAT3 SUMO2 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 UBE3A UNC45A USP50 WASL YWHAB	3 interacting genes: CCL19 CCL21 CCR10
Entrez ID		3326	1236
HPRD ID		06763	02588
Ensembl ID		ENSG00000096384	ENSG00000126353
Uniprot IDs		A0A024RD80 B4DGL0 P08238 Q6PK50	A0N0Q0 J3KSS9 P32248
PDB IDs		1QZ2 1UYM 2L6J 3FWV 3NMQ 3PRY 3UQ3 5FWK 5FWL 5FWM 5FWP 5UC4 5UCH 5UCI 5UCJ 6N8W 6N8Y	6QZH
Enriched GO Terms of Interacting Partners?
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