HSF1 and HSF2

Data Source:
HPRD (in vitro, in vivo)

		HSF1	HSF2
Description		heat shock transcription factor 1	heat shock transcription factor 2
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Perinuclear Region Of Cytoplasm Nuclear Stress Granule Mitotic Spindle Pole Chaperone Complex Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Heat Shock Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein Self-association Protein Heterodimerization Activity Hsp90 Protein Binding Translation Elongation Factor Binding STAT Family Protein Binding Sequence-specific Single Stranded DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade DNA Repair Regulation Of Transcription By RNA Polymerase II MRNA Processing Defense Response Response To Nutrient Positive Regulation Of Cell Population Proliferation MRNA Transcription Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Activity Viral Process Negative Regulation Of Protein-containing Complex Assembly Response To Testosterone Cellular Response To Heat Cellular Response To Unfolded Protein Cellular Protein-containing Complex Assembly Cellular Response To Potassium Ion Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Estradiol Stimulus Cellular Response To Gamma Radiation Cellular Response To Diamide Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cellular Response To Heat Positive Regulation Of MRNA Polyadenylation Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic DNA Fragmentation Cellular Response To Sodium Arsenite Cellular Response To Angiotensin Positive Regulation Of Microtubule Binding Cellular Response To Nitroglycerin Cellular Response To L-glutamine Response To Hypobaric Hypoxia Response To Psychosocial Stress Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of Transcription By RNA Polymerase II Spermatogenesis Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy
Drugs		Bimoclomol
Diseases
GWAS		Dupuytren's disease ( 28886342)	Atrial fibrillation ( 28416822 30061737 29892015) Disease progression in age-related macular degeneration ( 29346644) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 30224653 27841878) Red blood cell count ( 32888494) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Word reading ( 30741946)
Interacting Genes		51 interacting genes: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 EEF1D ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PIM2 PPID PRKDC PTGES3 RALBP1 REPS1 RNF20 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE	19 interacting genes: CDC20 CDC27 CEP76 CUL3 DERA HSF1 HSF2BP MTUS2 NCAPG NUP62 PCGF2 PICK1 PPP2R1A SUMO2 SUMO3 TPM3 TRIM54 UBE2I WDR5
Entrez ID		3297	3298
HPRD ID		00778	00779
Ensembl ID		ENSG00000185122	ENSG00000025156
Uniprot IDs		Q00613	Q03933 Q9BS48
PDB IDs		2LDU 5D5U 5D5V 5HDG 5HDN	5D8K 5D8L 5HDK
Enriched GO Terms of Interacting Partners?
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