HLA-DQA1 and NXF1

Data Source:
BioGRID (biochemical)

		HLA-DQA1	NXF1
Description		major histocompatibility complex, class II, DQ alpha 1	nuclear RNA export factor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Transcription Export Complex Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Nuclear Inclusion Body
	Molecular Function	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding	RNA Binding MRNA Binding Protein Binding
	Biological Process	Adaptive Immune Response Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	RNA Export From Nucleus MRNA Export From Nucleus Viral Process Poly(A)+ MRNA Export From Nucleus
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript
Drugs
Diseases		Type I diabetes mellitus Dilated cardiomyopathy (DCM) Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
GWAS		Adult asthma ( 30578877) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300) Anti-polyomavirus 2 IgG seropositivity ( 33204752) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Apolipoprotein B levels ( 32203549) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474 29273806 23181788) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basal cell carcinoma ( 31174203) Blood protein levels ( 29875488) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Celiac disease ( 20190752 17558408) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 27182965 28928442) Childhood steroid-sensitive nephrotic syndrome ( 31263063 29903748) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 21131588) Chronic rhinosinusitis ( 30643255) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Creatinine levels ( 29403010) Crohn's disease ( 23850713 26891255 23266558) Cutaneous lupus erythematosus ( 25827949) Cutaneous squamous cell carcinoma ( 32041948) Drug-induced liver injury (flucloxacillin) ( 30661239) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein Barr virus nuclear antigen 1 IgG seropositivity ( 29868224) Epstein-Barr virus EBNA-1 antibody levels ( 33204752) Epstein-Barr virus immune response (multivariate analysis) ( 29868224) Epstein-Barr virus VCA p18 antibody levels ( 33204752) Epstein-Barr virus ZEBRA antibody levels ( 33204752) Estimated glomerular filtration rate ( 30604766) Factor VIII levels ( 30586737) Giant cell arteritis ( 28041642 25817017) Glomerular filtration rate ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Hepatocellular carcinoma ( 22807686) Herpes simplex virus 6 IE1B antibody levels ( 33204752) Herpes simplex virus 7 U14 antibody levels ( 33204752) High density lipoprotein cholesterol levels ( 29403010) Hypothyroidism ( 27182965 22493691) Idiopathic membranous nephropathy ( 21323541) IgA nephropathy ( 26028593 25305756) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A vasculitis ( 28698626) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28008999 18758464 28067908) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Leprosy ( 32421744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lymphocyte counts ( 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Lymphoma ( 23349640) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Membranous nephropathy ( 27333618) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nasal polyps ( 30643255) Nephropathy ( 21399633) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Oligoclonal band status in multiple sclerosis ( 25616667) Oropharynx cancer ( 32276964) Parental lifespan ( 30642433 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 27182965 28892059) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 27863252) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 23918589) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 23212062 19571809) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097066 24097067 28076899) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203 26829030) Squamous cell lung carcinoma ( 28604730) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 26316170 18204098 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549) Tuberculosis ( 28928442) Type 2 diabetes ( 28566273) Ulcerative colitis ( 28008999 24837172 28067908 26278503 23128233 21297633 19122664 23511034) Urate levels ( 31578528) Varicella zoster virus glycoproteins E and I antibody levels ( 33204752) Vitiligo ( 20410501 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) White blood cell count ( 32888494)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: APLP1 CD74 CDK7 HLA-DQB1 IKBKG LRIF1 SH3GL2 TLE1 UNC119	108 interacting genes: ALYREF AUNIP BACH2 BECN1 BIN3 BIRC2 BLMH BTBD18 C10orf55 C12orf40 CAMK2G CCDC120 CCDC196 CCDC197 CCDC7 CDYL2 CLK2 CLK3 CSNK2A1 DHX9 DVL3 ECSIT EIF4A3 ELAVL4 ESRRA FAM9A FTO GFAP GOLGA6L9 GPBP1 GTPBP2 HNRNPUL1 HOMEZ HOXA1 HSF2BP IMPA1 IPO11 IPO4 ISY1-RAB43 KATNBL1 KCTD5 KCTD7 KRT40 LCE3E LDOC1 LUZP4 MAGOH MAP1A MAP1B MBD3L1 MID2 MRNIP MTUS2 NKAPD1 NME4 NUP153 NUP214 NUP62 NUP98 NXF2 NXF3 NXF5 NXT1 NXT2 PIH1D2 PPP1R12C PRKAR1B PRPH PRR3 RAD51 RAE1 RAN RANBP2 RBM15B RBM8A RPRD1A SGTA SH2D3A SH3GLB2 SLAIN1 SNW1 SPATC1L SRPK2 SRSF1 SRSF3 SRSF7 STRAP SYCP3 TBC1D14 TCP10L TEX9 THOC5 TIFA TNFAIP1 TNPO1 TNPO2 TRA2A TRA2B U2AF1 UBQLN1 UBQLN4 UPF3A VPS28 XIST ZBED2 ZNF250 ZNF343 ZNF438
Entrez ID		3117	10482
HPRD ID		06765	04035
Ensembl ID		ENSG00000196735	ENSG00000162231
Uniprot IDs		A0A173ADG5 P01909 Q8MH44	Q59E96 Q9UBU9
PDB IDs		1JK8 1NBN 1S9V 1UVQ 2NNA 3PL6 4GG6 4OZF 4OZG 4OZH 4OZI 5KSA 5KSB 5KSU 5KSV 6MFF 6MFG 6U3M 6U3N	1FO1 1FT8 1GO5 1JKG 1JN5 1KOH 1KOO 1OAI 2Z5K 2Z5M 3RW6 3RW7 4WYK 6E5U
Enriched GO Terms of Interacting Partners?
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