HIF1A and HDAC3

Data Source:
BioGRID (pull down)

		HIF1A	HDAC3
Description		hypoxia inducible factor 1 subunit alpha	histone deacetylase 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body Nuclear Speck Motile Cilium Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Axon Cytoplasm	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcription Repressor Complex Mitotic Spindle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding	RNA Polymerase II Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Enzyme Binding Cyclin Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Response To Reactive Oxygen Species Angiogenesis Response To Hypoxia Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Neuroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cytokine Production Involved In Inflammatory Response Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Signal Transduction Lactation Visual Learning Response To Iron Ion Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Response To Muscle Activity Positive Regulation Of Macroautophagy Protein Ubiquitination Protein Deubiquitination Cytokine-mediated Signaling Pathway Axonal Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Embryonic Hemopoiesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Hemoglobin Biosynthetic Process Glucose Homeostasis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Post-translational Protein Modification Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Nitric-oxide Synthase Activity Cartilage Development Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Iris Morphogenesis Retina Vasculature Development In Camera-type Eye Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Hypoxia-inducible Factor-1alpha Signaling Pathway Cellular Response To Virus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein Neddylation Negative Regulation Of Mesenchymal Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Chromatin Organization Protein Deacetylation Circadian Rhythm Negative Regulation Of Myotube Differentiation Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Spindle Assembly Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha NOTCH1 Intracellular Domain Regulates Transcription Circadian Clock Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation	NR1D1 (REV-ERBA) represses gene expression p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs		Carvedilol Hydralazine 2-Methoxyestradiol ENMD-1198 PX-478 FG-2216	Vorinostat Belinostat Pracinostat Panobinostat Mocetinostat
Diseases
GWAS			Refractive error ( 32231278)
Interacting Genes		125 interacting genes: AKT1 APEX1 AR ARNT ARNT2 ARNTL ATM AURKA BNIP3 CASR CCND2 CDC34 CDK4 CDK6 CDKN2A CDKN2B CITED2 COPS5 CREB3L1 CREBBP CSNK1D CSNK2A1 CTNNB1 DAP3 E2F7 EAF2 EGLN1 EGLN2 EGLN3 EIF5A2 EP300 EPHA2 EPO ESRRA ESRRB ESRRG ETV4 F12 FGFR4 FZR1 GATA3 GLIS2 HDAC1 HDAC2 HDAC3 HDAC5 HIF1A-AS2 HIF1AN HIF3A HNF4A HSP90AA1 IKBKG ISG15 JUN KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LATS2 LINC01139 LRRK2 MAFG MAFK MAP2K3 MAP2K5 MAPK1 MAPK3 MAX MCL1 MCM7 MDM2 MTA1 MYC NAA10 NAA11 NBN NCOA1 NCOA2 NDN NEDD8 NF2 NQO1 NR4A1 OS9 PER1 PGK1 PKM PLD1 PLD2 PLK3 PRKACA PSMA7 PTBP1 PTK6 RACGAP1 RACK1 RB1 RORA RUNX2 RWDD3 SAT1 SEPTIN9 SIRT2 SMAD3 SP1 SSX4 STAT3 STK11 STUB1 SUCO SUMO1 TEAD2 TP53 TSGA10 UBE2D1 UBE2I USP19 USP20 USP28 USP7 VEGFA VHL VHLL ZC3H12A	102 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 DAXX DHX30 EED ELL EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16
Entrez ID		3091	8841
HPRD ID		04517	08950
Ensembl ID		ENSG00000100644	ENSG00000171720
Uniprot IDs		D0VY79 Q16665	O15379
PDB IDs		1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J 5JWP 5L9B 5L9V 5LA9 5LAS 6GFX 6GMR	4A69
Enriched GO Terms of Interacting Partners?
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