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GLI1 and PRKACA
Data Source:
BioGRID
(enzymatic study)
GLI1
PRKACA
Description
GLI family zinc finger 1
protein kinase cAMP-activated catalytic subunit alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Axoneme
Ciliary Tip
Ciliary Base
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nuclear Speck
Neuromuscular Junction
Calcium Channel Complex
Sperm Flagellum
Dendritic Spine
Plasma Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Ciliary Base
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
Microtubule Binding
Metal Ion Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Domain Specific Binding
Manganese Ion Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Regulatory Subunit Binding
Biological Process
Osteoblast Differentiation
Regulation Of Transcription By RNA Polymerase II
Smoothened Signaling Pathway
Spermatogenesis
Ventral Midline Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Smoothened Signaling Pathway
Response To Wounding
Epidermal Cell Differentiation
Dorsal/ventral Pattern Formation
Proximal/distal Pattern Formation
Cerebellar Cortex Morphogenesis
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Pituitary Gland Development
Lung Development
Prostate Gland Development
Regulation Of Osteoblast Differentiation
Positive Regulation Of DNA Replication
Positive Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Morphogenesis
Notochord Regression
Positive Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Liver Regeneration
Positive Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Hepatocyte Proliferation
G2/M Transition Of Mitotic Cell Cycle
Mesoderm Formation
Neural Tube Closure
Regulation Of Heart Rate
Stimulatory C-type Lectin Receptor Signaling Pathway
Renal Water Homeostasis
MRNA Processing
Protein Phosphorylation
Blood Coagulation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Kinase A Signaling
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cytokine-mediated Signaling Pathway
Activation Of Protein Kinase A Activity
High-density Lipoprotein Particle Assembly
Cellular Response To Heat
Calcium-mediated Signaling Using Intracellular Calcium Source
Regulation Of Protein Binding
Regulation Of Osteoblast Differentiation
Protein Autophosphorylation
Positive Regulation Of Protein Export From Nucleus
Sperm Capacitation
Modulation Of Chemical Synaptic Transmission
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Cardiac Muscle Contraction
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Processing
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Glucose Stimulus
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Glucagon Stimulus
Cellular Response To Epinephrine Stimulus
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Ciliary Basal Body-plasma Membrane Docking
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Regulation Of Cardiac Conduction
Regulation Of Bicellular Tight Junction Assembly
Pathways
Degradation of GLI1 by the proteasome
Degradation of GLI1 by the proteasome
Hedgehog 'off' state
Hedgehog 'on' state
GLI proteins bind promoters of Hh responsive genes to promote transcription
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Triglyceride catabolism
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of Adenylate Cyclase
Interleukin-3, Interleukin-5 and GM-CSF signaling
Ion homeostasis
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
RET signaling
AURKA Activation by TPX2
HDL assembly
ROBO receptors bind AKAP5
Loss of phosphorylation of MECP2 at T308
Regulation of MECP2 expression and activity
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
Drugs
Pentanal
Balanol Analog 2
3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate
Phosphonothreonine
Balanol Analog 1
3,5-Diiodotyrosine
Balanol
Dexfosfoserine
S,S-(2-Hydroxyethyl)Thiocysteine
Hydroxyfasudil
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
(2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
(2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
H-89
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
3-pyridin-4-yl-1H-indazole
5-benzyl-1,3-thiazol-2-amine
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Fasudil
Myristic acid
A-674563
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
Y-27632
Ellagic acid
Fostamatinib
Diseases
GWAS
Interacting Genes
22 interacting genes:
AQP1
CATSPER1
CRYBA4
DYRK1A
FEM1B
GCC1
IKBKB
PIN1
PRKAA2
PRKACA
PRMT1
PRMT5
RAI1
STK36
SUFU
TAF9
TRIM42
USP48
WDR77
XBP1
ZIC1
ZIC2
205 interacting genes:
AANAT
ABCA1
ACLY
ADCY5
ADD1
ADD2
AKAP14
AKAP8L
AKIP1
ANXA7
APC
APOBEC3G
ARFGEF3
ASIC1
ASIC3
ATF1
ATP2B1
AURKA
AVPI1
BAD
BCL2
BRAF
CACNA1C
CACNB2
CACNG2
CAD
CALD1
CAMKK2
CCDC88A
CCND1
CDK16
CDKN1A
CETN1
CFTR
CIITA
CLDN3
CLTC
CREB1
CREM
CRK
CSK
CUL5
CYP3A4
DMTN
DNAJC5
DOCK1
DRD1
DSP
EEF2K
EGFR
ERBB3
ESR1
ETV1
FBXW11
FOS
FXYD1
GABRB3
GABRR1
GAD1
GAD2
GFAP
GJA5
GJB1
GLI1
GMFB
GNA13
GNMT
GP1BB
GRIA1
GRIA4
GRK2
GSK3A
GSK3B
GUSB
GYS1
HAND1
HAND2
HDAC1
HDAC8
HIF1A
HMGCR
HMGN1
HMGN2
HNF4A
HNRNPD
HSP90AA1
HSPA4
HSPD1
IFNAR1
IQGAP1
IRF2
ITCH
ITGA2B
ITGA4
ITPKA
ITPKB
ITPR1
ITPR2
KCNH2
KCNJ12
KCNQ1
KDELR1
KLF1
KLHL3
LCK
LCP1
LIPE
LRP1
MAP2
MAP3K3
MAPT
MBP
MC4R
MEF2D
MEP1B
MGMT
MIP
NDRG1
NFKB1
NIN
NOLC1
NOS1
NOXA1
NR3C1
NSFL1C
NUP85
PDC
PDE3A
PDE3B
PDE4B
PDE4D
PDPK1
PFKFB1
PFKFB2
PHKA1
PHOX2A
PKIA
PKIB
PLIN1
PLN
POU2F1
PPP1R10
PPP1R17
PPP1R1B
PPP1R8
PPP1R9B
PRKAR1A
PRKAR1B
PRKAR2B
PSEN1
PSMD11
PTBP1
PTPN12
PTPN13
PTPN7
PTPRR
RAF1
RANBP9
RAP1A
RAP1B
RAP1GAP
RASGRF1
RASGRP3
RELA
RGS10
RGS13
RGS14
RHOA
RRAD
RSBN1
RYR1
RYR2
SI
SIK1
SIK3
SLC2A2
SLC4A4
SLC9A3R2
SNAP25
SNAPIN
SNPH
SPTBN1
SRC
STK11
STMN1
STMN2
STUB1
SYN1
SYN2
TH
THOP1
TNP1
TNP2
TPH1
TRIM55
TRIM63
TRIP10
UBE3A
UHRF1
USP20
VASP
VIM
VTN
WT1
YWHAZ
Entrez ID
2735
5566
HPRD ID
01311
03382
Ensembl ID
ENSG00000111087
ENSG00000072062
Uniprot IDs
B4DNF7
P08151
A0A024R7J0
A8K8B9
P17612
PDB IDs
2GLI
4BLB
4KMD
5OM0
2GU8
3AGL
3AGM
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
4AE6
4AE9
4UJ1
4UJ2
4UJ9
4UJA
4UJB
4WB5
4WB6
4WB7
4WB8
5BX6
5BX7
5IZF
5IZJ
5J5X
5N23
5UZK
6BYR
6BYS
6C0U
6FRX
6NO7
6QJ7
Enriched GO Terms of Interacting Partners
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