GLI1 and PRMT5

Data Source:
BioGRID (enzymatic study)

		GLI1	PRMT5
Description		GLI family zinc finger 1	protein arginine methyltransferase 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Axoneme Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Histone Methyltransferase Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Microtubule Binding Metal Ion Binding	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity E-box Binding
	Biological Process	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation	Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression Histone Arginine Methylation Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation Regulation Of DNA Methylation Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription	snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS			Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		22 interacting genes: AQP1 CATSPER1 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PIN1 PRKAA2 PRKACA PRMT1 PRMT5 RAI1 STK36 SUFU TAF9 TRIM42 USP48 WDR77 XBP1 ZIC1 ZIC2	91 interacting genes: ARGLU1 C1orf109 CACNB2 CALU CAPN1 CDC37 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A CTDP1 DIO3 DNMT3A DUSP14 EIF4A3 ELOA EPHB6 EZH2 FAM76B GAS8 GLI1 GRHL3 GTPBP2 H2AC20 H2AC4 H3-4 H3-5 H3C1 H4-16 H4C1 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 KANK2 LDHAL6B LENG8 LNX1 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NCL NELFCD NTAQ1 NUDCD2 OLA1 PDGFRA PHYHIP POLR2A PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 STUB1 SUPT5H TRIB3 TRIM54 TYK2 UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZMYND19 ZNF2 ZNF224 ZNF436 ZUP1
Entrez ID		2735	10419
HPRD ID		01311	04955
Ensembl ID		ENSG00000111087	ENSG00000100462
Uniprot IDs		B4DNF7 P08151	B4DV00 O14744
PDB IDs		2GLI 4BLB 4KMD 5OM0	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UXX 6UXY 6V0N 6V0O
Enriched GO Terms of Interacting Partners?
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