GART and IFNAR1

Data Source:
BioGRID (affinity chromatography technology)

		GART	IFNAR1
Description		phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	interferon alpha and beta receptor subunit 1
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity ATP Binding Metal Ion Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding
	Biological Process	Brainstem Development Purine Nucleotide Biosynthetic Process 'de Novo' IMP Biosynthetic Process Glycine Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Organic Substance Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Adenine Biosynthetic Process Tetrahydrofolate Biosynthetic Process	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway
Pathways		Purine ribonucleoside monophosphate biosynthesis	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs		Pemetrexed Glycinamide Ribonucleotide N-({4-[(1R)-4-[(2R,4S,5S)-2,4-diamino-6-oxohexahydropyrimidin-5-yl]-1-(2,2,2-trifluoro-1,1-dihydroxyethyl)butyl]phenyl}carbonyl)-L-glutamic acid	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta
Diseases
GWAS		Crohn's disease ( 23128233) Educational attainment ( 25201988) Psoriasis ( 25854761)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		4 interacting genes: CDC42 KPNA2 PXN TRAF6	25 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		2618	3454
HPRD ID		00716	00126
Ensembl ID		ENSG00000159131	ENSG00000142166
Uniprot IDs		P22102 Q59HH3	A0A494C0E2 P17181
PDB IDs		1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 2QK4 2V9Y 4EW1 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ2 4ZZ3 5J9F	3S98 3SE3 3SE4 4PO6
Enriched GO Terms of Interacting Partners?
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