KPNA6 and NMNAT1

Data Source:
BioGRID (two hybrid)

		KPNA6	NMNAT1
Description		karyopherin subunit alpha 6	nicotinamide nucleotide adenylyltransferase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Host Cell	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Viral Genome Replication Mitigation Of Host Defenses By Symbiont Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	Nucleotide Biosynthetic Process NAD Biosynthetic Process Response To Wounding NAD Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic DNA Fragmentation ATP Generation From Poly-ADP-D-ribose
Pathways			Nicotinate metabolism
Drugs			Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Body mass index ( 26426971)	Resting heart rate ( 27798624)
Interacting Genes		37 interacting genes: ANKRD11 ANP32A ANP32B ARNT BRCA1 CDKN1B CREBBP CSE1L DCPS EPAS1 FAM90A1 FRG1BP GEMIN2 HIF1A IL1A JRK KAT5 KEAP1 KPNB1 LMNA LMNB1 MAGED1 NMNAT1 NOP2 NUP50 POLR3C POM121 POU6F2 RAC1 RELB RNMT SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2
Entrez ID		23633	64802
HPRD ID		09465	16369
Ensembl ID		ENSG00000025800	ENSG00000173614
Uniprot IDs		O60684	A0A024R4E1 B1AN62 Q9HAN9
PDB IDs		4UAD	1GZU 1KKU 1KQN 1KQO 1KR2
Enriched GO Terms of Interacting Partners?
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