FOXO3 and NR1H3

Data Source:
HPRD (two hybrid)

		FOXO3	NR1H3
Description		forkhead box O3	nuclear receptor subfamily 1 group H member 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Chromatin DNA Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Sterol Response Element Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Mitochondrial Transcription Regulation Of Translation Apoptotic Process Positive Regulation Of Autophagy Positive Regulation Of Muscle Atrophy Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Response To Starvation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Fatty Acid Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PPARA activates gene expression VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Diacerein Rhein
Diseases
GWAS		Adult body size ( 32376654) Anxiety/tension (special factor of neuroticism) ( 30867560) Blood protein levels in cardiovascular risk ( 28369058) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Insulin-like growth factors ( 21216879) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lead levels ( 26025379) Macular thickness ( 30535121) Normalized brain volume ( 19010793) Platelet distribution width ( 32888494 27863252) Poor prognosis in Crohn's disease ( 28067912) Prostate cancer ( 23535732) Pulse pressure ( 30224653) Reaction time ( 29844566) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Schizophrenia ( 28991256 30285260) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 28552196)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood glucose levels ( 31928498) Creatinine levels ( 29403010) Feeling miserable ( 29500382) HDL cholesterol ( 19060910 20686565) Hypertension ( 31879980) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 27863252) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 27863252) Mood instability ( 31168069) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Triglyceride levels ( 32154731) Triglycerides ( 30275531)
Interacting Genes		27 interacting genes: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBIN ESR1 FOXG1 IKBKB MAPK1 MAPK6 MDM2 NR1H2 NR1H3 PTPA SGK1 SIRT1 SMAD2 SMAD3 SMAD4 TERT TP53 VDR YWHAG YWHAZ	35 interacting genes: ACTN1 APP BAG3 CEP350 EDF1 FOXO3 GPANK1 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA PPARD PPARG PSMC5 RARA RXRA RXRB RXRG SIRT1 SS18L1 SUV39H1 SYT1 TMEM161A UBE2I ZXDC
Entrez ID		2309	10062
HPRD ID		04061	07211
Ensembl ID		ENSG00000118689	ENSG00000025434
Uniprot IDs		O43524	B4DXU5 B5MBY7 F1D8N1 Q13133
PDB IDs		2K86 2LQH 2LQI 2UZK 6MNL	1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJS
Enriched GO Terms of Interacting Partners?
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