FOXG1 and KDM5B

Data Source:
HPRD (in vivo, two hybrid)

		FOXG1	KDM5B
Description		forkhead box G1	lysine demethylase 5B
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) Histone Binding Dioxygenase Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Brain Development Aging Dorsal/ventral Pattern Formation Axon Midline Choice Point Recognition Pyramidal Neuron Migration Inner Ear Morphogenesis Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Neuron Fate Determination	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Single Fertilization Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Response To Fungicide Uterus Morphogenesis Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Estradiol Secretion
Pathways		Regulation of MECP2 expression and activity FOXO-mediated transcription of cell cycle genes	HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors
Drugs
Diseases		Rett syndrome
GWAS		Longevity ( 20834067) Manganese levels ( 26025379) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Resting oxygen saturation in chronic osbtructive pulmonary disease (pulse oxymetry) ( 24825563) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)
Interacting Genes		19 interacting genes: APOE AR EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 SRF TLE1 TLE3 TLE6	5 interacting genes: FOXG1 KDM1A MBD3 PAX9 RB1
Entrez ID		2290	10765
HPRD ID		01283	09251
Ensembl ID		ENSG00000176165	ENSG00000117139
Uniprot IDs		P55316	A0A3B3ITA8 Q9UGL1
PDB IDs		7CBY	2MA5 2MNY 2MNZ 5A1F 5A3N 5A3P 5A3T 5A3W 5FPL 5FPU 5FUN 5FUP 5FV3 5FY4 5FY5 5FY9 5FYB 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5LW9 5LWB 6EIN 6EIU 6EIY 6EJ0 6EJ1 6EK6 6H4Z 6H50 6H51 6H52 6RBI
Enriched GO Terms of Interacting Partners?
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