DDX3X and IL7R

Data Source:
BioGRID (unspecified method)

		DDX3X	IL7R
Description		DEAD-box helicase 3 X-linked	interleukin 7 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Eukaryotic Translation Initiation Factor 3 Complex Plasma Membrane Cytoplasmic Stress Granule Cytosolic Small Ribosomal Subunit Lamellipodium Cell Leading Edge Secretory Granule Lumen P Granule Extracellular Exosome NLRP3 Inflammasome Complex Ficolin-1-rich Granule Lumen	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding GTPase Activity Protein Binding ATP Binding Transcription Factor Binding Poly(A) Binding Eukaryotic Initiation Factor 4E Binding ATPase Activity Nucleoside-triphosphatase Activity Translation Initiation Factor Binding RNA Strand Annealing Activity RNA Stem-loop Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding CTPase Activity Protein Serine/threonine Kinase Activator Activity Cadherin Binding MRNA 5'-UTR Binding	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Translational Initiation Chromosome Segregation Gamete Generation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Viral Process Wnt Signaling Pathway Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Stress Granule Assembly Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Lipid Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Osmotic Stress Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Acetylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein K63-linked Ubiquitination Protein Localization To Cytoplasmic Stress Granule Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Positive Regulation Of Gene Expression T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells Defense Response To Gram-positive Bacterium Membrane Organization Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Neutrophil degranulation	Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Refractive error ( 32231278)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eczema ( 31361310) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Primary biliary cholangitis ( 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)
Interacting Genes		92 interacting genes: APBB1 CSNK2A1 DUX4 ESR1 HNF4A IKBKE IL7R LINC01554 MAVS MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NFKB2 NUP62 PIN1 SREK1 SRPK2 SUMO2 WBP4 XPO1 YWHAQ ZNF512B	110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		1654	3575
HPRD ID		02154	00893
Ensembl ID		ENSG00000215301	ENSG00000168685
Uniprot IDs		A0A2R8Y7T2 A0A2R8YFS5 O00571	P16871
PDB IDs		2I4I 2JGN 3JRV 4O2C 4O2E 4O2F 4PX9 4PXA 5E7I 5E7J 5E7M 6CZ5 6O5F	3DI2 3DI3 3UP1 5J11 6P50 6P67
Enriched GO Terms of Interacting Partners?
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