CTLA4 and BCS1L

Data Source:
BioGRID (affinity chromatography technology)

		CTLA4	BCS1L
Description		cytotoxic T-lymphocyte associated protein 4	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Integral Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding ATP Binding ATPase Activity
	Biological Process	Adaptive Immune Response Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Mitochondrion Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Cytochrome C Oxidase Assembly Mitochondrial Respiratory Chain Complex III Assembly
Pathways		CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Mitochondrial protein import
Drugs		Ipilimumab Tremelimumab
Diseases		Type I diabetes mellitus Graves' disease Allograft rejection Hashimoto's thyroiditis	Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Alopecia areata ( 20596022 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 30659077 21829393 25751624 19430480 30572963 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)	Male-pattern baldness ( 28196072)
Interacting Genes		17 interacting genes: AP1M1 AP2M1 CD80 CD86 CTXN3 FYN JAK2 LCK LYN MALL PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TMEM218 TXK	3 interacting genes: DDX24 DNAJA1 MTDH
Entrez ID		1493	617
HPRD ID		00474	04708
Ensembl ID		ENSG00000163599	ENSG00000074582
Uniprot IDs		P16410	A0A024R445 A8JZZ8 Q9Y276
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM
Enriched GO Terms of Interacting Partners?
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