FAM168B and MED25

Data Source:
BioGRID (two hybrid)

		FAM168B	MED25
Description		family with sequence similarity 168 member B	mediator complex subunit 25
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Axon Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleoplasm Transcription Regulator Complex Mediator Complex
	Molecular Function		Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Blood trace element (Se levels) ( 23720494)
Interacting Genes		51 interacting genes: AGXT ARID5A BAG3 CAMK2A CCNK CSTF2 CSTF2T EGLN3 FAM168A FAM222B FOXH1 FOXI1 GLIS2 GPS2 HOXB9 HSF4 KRTAP26-1 LASP1 MED25 MSRB3 MYOZ3 NEDD9 OTX1 PATZ1 PITX1 POGZ POM121 PPP1R32 PRR35 RAMAC RBFOX2 RHOXF2 ROR2 SAMD7 SNRPB SNRPC SPAG8 TCF7L2 TENT5B TIAL1 TLE5 TLX3 UBAP2 VENTX VEZF1 VGLL3 VPS37C WDR25 YPEL3 ZC3H10 ZIC1	37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2
Entrez ID		130074	81857
HPRD ID		17295	14380
Ensembl ID		ENSG00000152102	ENSG00000104973
Uniprot IDs		A0A024QZ31 A1KXE4	Q71SY5
PDB IDs			2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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