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LENG8 and PRMT6
Data Source:
BioGRID
(two hybrid)
LENG8
PRMT6
Description
leukocyte receptor cluster member 8
protein arginine methyltransferase 6
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleus
Nucleoplasm
Nucleolus
Molecular Function
Protein Binding
Chromatin Binding
Protein Binding
Histone-arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Histone Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Histone Methyltransferase Activity (H3-R2 Specific)
Histone Methyltransferase Activity (H2A-R3 Specific)
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Base-excision Repair
Regulation Of Mitochondrion Organization
Viral Process
Histone Methylation
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Negative Regulation Of Histone Deacetylation
Histone H3-R2 Methylation
Histone H4-R3 Methylation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Histone H3-K4 Methylation
Cellular Senescence
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
RMTs methylate histone arginines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Blood pressure measurement (low sodium intervention) (
24165912
)
Intelligence (
22449649
)
Low density lipoprotein cholesterol levels (
32154731
)
Non-obstructive azoospermia (
22197933
)
Obesity (early onset extreme) (
23563609
)
Refractive error (
32231278
)
Response to SSRI in MDD or openness (
29559929
)
Restless legs syndrome (
29029846
)
Sex hormone-binding globulin levels (
22829776
)
Waist circumference (
28552196
)
Weight (
28552196
)
Interacting Genes
49 interacting genes:
ANKHD1
ARID5A
ATN1
BAG3
C10orf55
CAMK2A
CEP70
CFAP53
COG2
CPSF7
CYSRT1
DMRTB1
DVL3
FAM166B
GSE1
HMGXB4
HNRNPM
IKBKG
INCA1
INTS11
KDM1A
LASP1
MAGED1
MAPK1IP1L
MIA3
MSX2
MYOZ3
NCBP3
NUTM2F
PCID2
PER2
PRDM16
PRMT5
PRMT6
PYGO1
RHOXF2
SMARCB1
SMN1
SMYD1
SNRPA
SOCS7
SUV39H1
TFG
TLE5
TNIP1
TRAF4
TSG101
VGLL3
ZNF34
90 interacting genes:
AK8
AP1G2
ASB3
AUNIP
BCAT1
BLZF1
BMP3
C8orf74
CDCA4
CETN2
DCAF16
DNAJA3
DNALI1
DXO
FBL
FIP1L1
FKBP7
FYCO1
FYN
GBE1
GPS2
GRHL3
GSTCD
GTPBP2
H2AC18
H2BC21
H3-5
H3C14
H3C15
H4-16
H4C6
HESX1
HMGA1
HMGA2
HNRNPH2
HOXA1
HOXA5
HOXC4
ID2
KIAA0408
KIF9
KLHL20
LDHAL6B
LENG8
LINC02875
LOXL4
MALT1
MED28
METTL27
MLC1
MNDA
MTF2
NEFL
NOSTRIN
NR1D2
OAS1
OPA3
PABPC1
PCGF5
PELO
PEX7
PSMD11
PYCR3
PYGO1
RAC1
RAD17
RASSF2
SERGEF
SLU7
SMAD9
SMARCD1
SNF8
SPATA22
SPIN1
SPSB1
SRGAP3
SSX2IP
STARD10
SUV39H1
TDO2
TEX35
THEMIS
TMED5
TRIB2
TSC1
UBXN10
WDFY3
ZNF436
ZNF557
ZSCAN9
Entrez ID
114823
55170
HPRD ID
11226
10505
Ensembl ID
ENSG00000167615
ENSG00000198890
Uniprot IDs
A0A024R4R9
C9JMY0
Q96PV6
Q96LA8
PDB IDs
4HC4
4QPP
4QQK
4Y2H
4Y30
5E8R
5EGS
5HZM
5WCF
6P7I
6W6D
6WAD
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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