TUBB4B and TSC1

Data Source:
HPRD (in vivo, in vitro)

		TUBB4B	TSC1
Description		tubulin beta 4B class IVb	TSC complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex
	Molecular Function	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding MHC Class I Protein Binding Unfolded Protein Binding	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Ciliary Basal Body-plasma Membrane Docking	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs		Albendazole Mebendazole Epothilone D Patupilone Oxibendazole CYT997 Phenethyl Isothiocyanate
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS			Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		19 interacting genes: ACD CDKN2A DAPK1 DLEU1 DLST ENOX2 LINC01554 NEAT1 POT1 PSME1 PTEN PTPRF SCG2 SOCS6 SOCS7 SUMO2 TERF1 TINF2 TUBG1	99 interacting genes: AKT1 APPL2 AQP1 ARAF ARID5A ATXN1 AURKA BAG3 BECN1 C1orf94 CCDC120 CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CHCHD2 CSTF2 DMRT3 DOK5 ENKD1 EZR FAM110A FAM222B FGFR4 FOXH1 FRS3 GLIS2 GPANK1 HOXC8 HR HSH2D IGFN1 IKBKB KAT2A KDM1A LATS2 LENG1 LMO2 MAP2K5 MAPK14 MSN MYC MYLIP MYOZ3 NEFL NF2 PATL1 PATZ1 PITX1 PLK1 PLK2 POGZ POU6F2 PPP1R18 PPP1R32 PRMT6 RASSF1 RBPMS RDX RHEB RIN1 RIN3 SAMD11 SAMD7 SH2D2A SHC3 SMG9 SOX4 SPAG8 SUOX TBC1D7 TBX6 TCF7L2 TFAP2D TLE5 TNS2 TSC2 TSGA10IP TSHZ3 VENTX VEZF1 VGLL3 VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF587 ZNF765
Entrez ID		10383	7248
HPRD ID		04043	05594
Ensembl ID		ENSG00000188229	ENSG00000165699
Uniprot IDs		P68371	A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs			4Z6Y 5EJC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?