CDKN1A and INCA1

Data Source:
BioGRID (two hybrid)

		CDKN1A	INCA1
Description		cyclin dependent kinase inhibitor 1A	inhibitor of CDK, cyclin A1 interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body Protein-containing Complex Perinuclear Region Of Cytoplasm PCNA-p21 Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Cyclin-dependent Protein Kinase Activating Kinase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Sequestering Activity	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Import Into Nucleus Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Heart Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Response To X-ray Response To Organonitrogen Compound Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Cellular Response To Amino Acid Starvation Cellular Response To Heat Wound Healing Tissue Regeneration Negative Regulation Of Phosphorylation Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Arsenic-containing Substance Positive Regulation Of Fibroblast Proliferation Protein Stabilization Response To Corticosterone Response To Hyperoxia Intestinal Epithelial Cell Maturation Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Mitotic Cell Cycle Arrest Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins
Drugs		Arsenic trioxide
Diseases		Cervical cancer
GWAS		Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 22634755 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 32602732 20062063) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Ischemic stroke ( 29531354) JT interval ( 29874175) Left ventricular fractional shortening ( 28394258) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 30679814 27577874 31251759 25035420 31217584 21076409 27659466) Triglyceride levels ( 32203549) Triglycerides ( 27036123)	Intraocular pressure ( 29235454) Obesity-related traits ( 23251661)
Interacting Genes		205 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PRKACA PRKAR1B PRKN PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RB1 RBBP4 RBM48 REL RNF126 RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SKP2 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TP53 TRAF1 TRIM3 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP11 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431	236 interacting genes: ABI2 ACY3 AKAP8L ANKRD28 ARMC7 ASPSCR1 ATG5 ATP6V0D2 ATPAF2 BAG3 BANF2 BOLA3 BPIFA1 C10orf55 C19orf54 C1orf35 C1orf50 C1orf56 C22orf39 CABP5 CCBE1 CCDC57 CCDC78 CCNA1 CDA CDC23 CDK18 CDK2 CDK4 CDKN1A CDKN2B CDKN2D CEP72 CHCHD2 CHCHD5 CHRD CINP CKS1B CLIC3 CLK3 COL8A1 CPSF1 CSDC2 CSTF2 CTNNBIP1 CTTNBP2 CYSRT1 DAZAP2 DEF6 DMRT3 DMRTB1 DOK4 DPH7 DUSP13 EFEMP2 EMD EPHB6 EXOSC8 FAAP20 FAIM FEM1A FGF16 FHL2 FMR1 FRS3 GEM GEMIN2 GRB2 GRXCR1 GSTO2 GTF2H5 GTPBP3 GYS1 HAUS1 HCK HDAC4 HEMK1 HENMT1 HNRNPF HOMER3 HOXA1 HR HSD17B14 HYI IL36RN ILF2 KCTD7 KCTD9 KIAA1217 KIR2DL4 KLHL26 KLHL42 KRT33B KRT5 KRT75 KRTAP15-1 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP5-6 KRTAP6-2 KRTAP6-3 KRTAP9-3 LENG8 LGALS3 LHX3 LMNTD2 LMO2 LMO3 LSM3 LYPLA2 MAD2L2 MAGED4B MAGOHB MALSU1 MARF1 MARK1 MATN3 MBLAC1 METAP1 MPP1 MSRB1 MTMR9 NATD1 NCK2 NDUFAF3 NEDD9 NEIL2 NEK6 NFKBID NHSL2 NME7 NMRK1 NPAS2 NTAQ1 NUBP2 NUDT16L1 NUDT22 OR6B1 OSGIN1 PADI3 PATE1 PCSK5 PCYT2 PDP1 PEF1 PFDN5 PHF1 PLA2G10 PLSCR3 POLR1C POLR3C POP5 POU4F2 PPP1R32 PRPH PSMB2 PSMB8 PTGER3 R3HDM2 RAB5C RALB RAMAC RBPMS RECK RFC3 RIPPLY3 RNF26 SAP18 SCNM1 SEC14L4 SHFL SLC22A18AS SMG9 SMUG1 SNRPB SPAG8 SPG21 SPOUT1 SPRY1 STAMBPL1 STK16 STT3B SUOX TBC1D7 TCL1A TEAD4 TEKT4 TEX12 TFAP2A TFAP2D TFAP4 TFG THAP6 THRSP TIAL1 TPRX1 TRAPPC2 TRAPPC2B TRAPPC6A TRIB3 TRIM26 TRIM55 TRIM63 TRIM68 TRIP13 TRIP6 TSEN15 TSG101 TSSK3 TSTD2 TXNDC17 UBASH3B UBE2D4 UBE2Z UBTD2 UBXN2B UFM1 UFSP1 VEZF1 VGLL3 VPS26C VPS28 WWOX YIPF3 YOD1 ZDHHC24 ZFAND3 ZMYND12 ZMYND19 ZNF205-AS1 ZNF32 ZNF446 ZNF747 ZNF765 ZNRD2
Entrez ID		1026	388324
HPRD ID		00298	17150
Ensembl ID		ENSG00000124762	ENSG00000196388
Uniprot IDs		A0A024RCX5 P38936	Q0VD86
PDB IDs		1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H
Enriched GO Terms of Interacting Partners?
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