CDKN1A and GCKR

Data Source:
BioGRID (two hybrid)

		CDKN1A	GCKR
Description		cyclin dependent kinase inhibitor 1A	glucokinase regulator
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body Protein-containing Complex Perinuclear Region Of Cytoplasm PCNA-p21 Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Cyclin-dependent Protein Kinase Activating Kinase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Sequestering Activity	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Carbohydrate Binding Fructose-6-phosphate Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Import Into Nucleus Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Heart Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Response To X-ray Response To Organonitrogen Compound Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Cellular Response To Amino Acid Starvation Cellular Response To Heat Wound Healing Tissue Regeneration Negative Regulation Of Phosphorylation Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Arsenic-containing Substance Positive Regulation Of Fibroblast Proliferation Protein Stabilization Response To Corticosterone Response To Hyperoxia Intestinal Epithelial Cell Maturation Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Mitotic Cell Cycle Arrest Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Carbohydrate Metabolic Process Regulation Of Glycolytic Process Protein Import Into Nucleus Response To Fructose Negative Regulation Of Glucokinase Activity Glucose Homeostasis Urate Metabolic Process Triglyceride Homeostasis Carbohydrate Derivative Metabolic Process
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins	Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Drugs		Arsenic trioxide
Diseases		Cervical cancer
GWAS		Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 22634755 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 32602732 20062063) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Ischemic stroke ( 29531354) JT interval ( 29874175) Left ventricular fractional shortening ( 28394258) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 30679814 27577874 31251759 25035420 31217584 21076409 27659466) Triglyceride levels ( 32203549) Triglycerides ( 27036123)	Albumin-globulin ratio ( 29403010) Alcohol consumption ( 27911795 28937693 31358974) Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Alcohol consumption (drinks per week) ( 28485404 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Bitter beverage consumption ( 31046077) Blood glucose levels ( 29615537) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels in cardiovascular risk ( 28369058) Blood sugar levels ( 29403010) Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Breast size ( 22747683) C-reactive protein ( 18439548) C-reactive protein levels ( 29403010 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Calcium levels ( 24068962 20705733) Cardiovascular disease risk factors ( 21943158) Chloride levels ( 29403010) Cholesterol ( 31902109) Cholesterol, total ( 24097068 25961943 20686565 26582766) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 29124443 20383146) circulating leptin levels ( 32917775 26833098) circulating leptin levels adjusted for BMI ( 32917775 26833098) Circulating leptin levels or fasting insulin levels ( 32341051) Circulating leptin levels or HOMA-IR ( 32341051) Circulating leptin levels or type 2 diabetes ( 32341051) Coffee consumption ( 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Crohn's disease ( 28067908 21102463) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood insulin ( 25631608 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting blood insulin adjusted for BMI ( 25625282) Fasting plasma glucose ( 25187374 28270201 22508271) Fasting triglyceride levels ( 32603185) Gallstone disease ( 30504769 27094239) Gamma glutamyl transferase levels ( 29403010) Gestational insulin sensitivity ( 32556615) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Gondoic acid (20:1n-9) levels ( 28298293) Gout ( 25646370 32238385 31578528 27899376) Gout (combined type) ( 32238385) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 31562340) Hematocrit ( 32888494 27863252) Hematological and biochemical traits ( 20139978) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Homeostasis model assessment of insulin resistance ( 20081858) Hypertriglyceridemia ( 31910446 27599772 23505323 20657596) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Kidney stones ( 31729369) L-selectin levels ( 25576479) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 18179892 30275531) LDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24386095 24023260) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910 21886157) Metabolite levels ( 21909109 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069) Non-oily fish consumption ( 32066663) Nonalcoholic fatty liver disease ( 29385134) Nonalcoholic steatohepatitis ( 32298765) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Percent glycated albumin ( 29844224) Phospholipid levels (plasma) ( 22359512) Plasma lactate levels ( 26433129) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet count ( 22139419 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Postprandial triglyceride levels ( 32603185) Problematic alcohol use ( 32451486) Protein C levels ( 28082259) Prothrombin time ( 29403010) Red blood cell count ( 27863252) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Relative protein intake ( 32393786) Renal overload gout ( 27899376) Renal underexcretion gout ( 32238385 27899376) Resting heart rate ( 29769521 27798624) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum albumin level ( 23022100 29403010) Serum alkaline phosphatase levels ( 31666285) Serum alpha1-antitrypsin levels ( 26174136) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271) Serum total protein level ( 23022100 29403010) Serum uric acid levels ( 30993211 29403010) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total body bone mineral density ( 29304378) Total cholesterol levels ( 28334899 31087446 29403010 29615537 30275531) Total triglycerides levels ( 26690388) Triglyceride levels ( 30718733 28334899 31087446 31647587 32154731 30911093 29403010 29615537) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 23726366 24097068 29404214 21909109 18193043 18193044 20864672 26160806 19060906 19060911 20139978 30275531 17463246 25961943 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 28566273 22885922 30054458 30297969 29632382 26818947 32499647 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31985003 20884846 31578528 20139978 23263486) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary sodium excretion ( 31409800) Urinary sodium to creatinine ratio ( 30910378) Urolithiasis ( 30975718) Waist Circumference - Triglycerides (WC-TG) ( 21386085) Waist circumference and related phenotypes ( 18454146) White blood cell count ( 29403010 32888494 27863252 24777453)
Interacting Genes		205 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PRKACA PRKAR1B PRKN PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RB1 RBBP4 RBM48 REL RNF126 RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SKP2 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TP53 TRAF1 TRIM3 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP11 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431	4 interacting genes: CDKN1A EP300 GCK TRAF2
Entrez ID		1026	2646
HPRD ID		00298	02909
Ensembl ID		ENSG00000124762	ENSG00000084734
Uniprot IDs		A0A024RCX5 P38936	A0A0C4DFN2 Q14397
PDB IDs		1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H	4BB9 4BBA 4LY9 4MQU 4MRO 4MSU 4OHK 4OHM 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3 4PX2 4PX3 4PX5 4PXS
Enriched GO Terms of Interacting Partners?
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