CDH5 and P2RX6

Data Source:
HPRD (in vivo)

		CDH5	P2RX6
Description		cadherin 5	purinergic receptor P2X 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Neuronal Cell Body Dendritic Spine Receptor Complex Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Ion Channel Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding	Purinergic Nucleotide Receptor Activity Transmembrane Signaling Receptor Activity Extracellularly ATP-gated Cation Channel Activity ATP Binding Channel Activity Protein-containing Complex Binding
	Biological Process	Cell Morphogenesis Regulation Of Protein Phosphorylation Vasculature Development Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Muscle Contraction Signal Transduction Blood Coagulation Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Excitatory Postsynaptic Potential Cation Transmembrane Transport
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability	Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Lenalidomide FX06	Promethazine
Diseases
GWAS		Body size at age 10 ( 32376654) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)
Interacting Genes		21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM	2 interacting genes: APP CDH5
Entrez ID		1003	9127
HPRD ID		03075	08490
Ensembl ID		ENSG00000179776	ENSG00000099957
Uniprot IDs		P33151 Q59EA3	O15547
PDB IDs
Enriched GO Terms of Interacting Partners?
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