CDH5 and CDH3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)
HPRD (in vitro, in vivo)

		CDH5	CDH3
Description		cadherin 5	cadherin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane	Cytoplasm Plasma Membrane Adherens Junction Integral Component Of Membrane Catenin Complex Cell Junction
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Ion Channel Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding	Molecular_function Calcium Ion Binding Cadherin Binding
	Biological Process	Cell Morphogenesis Regulation Of Protein Phosphorylation Vasculature Development Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Retina Homeostasis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Positive Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Hair Cycle Process Keratinization Positive Regulation Of Monophenol Monooxygenase Activity Negative Regulation Of Transforming Growth Factor Beta2 Production Adherens Junction Organization Wound Healing Response To Drug Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Melanin Biosynthetic Process Negative Regulation Of Timing Of Catagen Regulation Of Hair Cycle By Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Melanosome Transport
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability	Adherens junctions interactions
Drugs		Lenalidomide FX06
Diseases			Hypotrichosis, congenital, with juvenile macular dystrophy Ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM syndrome)
GWAS		Body size at age 10 ( 32376654) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)	Cutaneous melanoma or hair colour ( 32341527) Glycated hemoglobin levels ( 28898252) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244 24076602) Platelet count ( 32888494) Red cell distribution width ( 27863252) Ulcerative colitis ( 28067908)
Interacting Genes		21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM	3 interacting genes: CTNNA1 CTNNB1 CTNND1
Entrez ID		1003	1001
HPRD ID		03075	00227
Ensembl ID		ENSG00000179776	ENSG00000062038
Uniprot IDs		P33151 Q59EA3	B4DLF0 P22223
PDB IDs			4OY9 4ZML 4ZMN 4ZMO 4ZMP 4ZMQ 4ZMT 4ZMV 4ZMW 4ZMX 4ZMY 4ZMZ 5JYL 5JYM
Enriched GO Terms of Interacting Partners?
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