NOTCH1 and PIK3CG

  • Number of citations of the paper that reports this interaction (PubMedID 14583609)
  • 81
  • Data Source:
  • HPRD (in vivo)

NOTCH1

PIK3CG

Description notch receptor 1 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
  • Crohn's disease ( 28067908)
  • Eosinophil counts ( 32888494)
  • Inflammatory bowel disease ( 28067908)
  • Length of menstrual cycle ( 26732621)
  • Mean corpuscular hemoglobin ( 32888494)
  • Red cell distribution width ( 28957414)
  • Serum alkaline phosphatase levels ( 33547301)
  • Triglyceride levels ( 32203549)
  • Ulcerative colitis ( 28067908)
Interacting Genes 87 interacting genes: ADAM17 AKT1 APBA1 ARL6IP5 B3GALT4 BLOC1S1 CACNA1A CAMK4 CASR CBL CCN3 CEP57L1 CNTN1 COL4A6 CTNNB1 DAZAP2 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 EXT1 FAM185A FBP1 FBXW7 FURIN GFI1B GOLGA2 GOPC GSK3B HMGN5 HOXA1 ILK ITCH JAG1 JAG2 KAT2A KAT2B KIAA1191 LCK LEF1 LFNG LINC00260 LINC02907 LNX2 MAGEA1 MAGED1 MAML1 MAML2 MAML3 MAP3K1 MBD1 MDM2 MEF2C MFNG NFKB1 NUMB NUMBL PIK3CG POFUT1 POU2AF1 PRKCD PSEN1 PSEN2 RBP3 RBPJ REL RELA RHOA RUNX3 SHANK3 SMAD3 SNAI1 SNW1 STC1 TLE3 TOR1A USP10 USP12 USP2 USP7 WDR12 WWP1 XIAP XRCC6 YY1 22 interacting genes: CD28 EPHA8 GAB1 GRB2 GRK2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PIK3R6 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID 4851 5294
HPRD ID 01827 03135
Ensembl ID ENSG00000148400 ENSG00000105851
Uniprot IDs P46531 A0A024R720 A8K9G9 P48736
PDB IDs 1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79 4CUD 4CUE 4CUF 4D0E 4D0F 5FM9 5FMA 5KZO 5L0R 5UB5 6IDF 6PY8 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4HVB 4J6I 4KZ0 4KZC 4PS3 4PS7 4PS8 4URK 4WWN 4WWO 4WWP 4XX5 4XZ4 5EDS 5G2N 5G55 5JHA 5JHB 5KAE 5OQ4 5T23 6AUD 6C1S 6FH5 6GQ7 6T3B 6T3C 6XRL 6XRM
Enriched GO Terms of Interacting Partners?
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