ARHGEF2

Description		Rho/Rac guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Bicellular Tight Junction Focal Adhesion Cytoplasmic Vesicle Vesicle Ruffle Membrane Protein-containing Complex Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Transcription Factor Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	Cell Morphogenesis Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Cell Cycle Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Population Proliferation Innate Immune Response Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Asymmetric Neuroblast Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Neuron Migration
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neuritic plaque ( 31497858) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: CGN MARK3 NFKBID PAK1 PTPRF RAC1 RHOA RPP25L RRAS2 YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		9181
HPRD ID		10458
Ensembl ID		ENSG00000116584
Uniprot IDs		A0A5F9ZI21 Q92974
PDB IDs		5EFX
Enriched GO Terms of Interacting Partners?
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