MBTPS1

Description		membrane bound transcription factor peptidase, site 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity
	Biological Process	Proteolysis Lysosome Organization Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Regulation Of Vesicle-mediated Transport
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) CREB3 factors activate genes CREB3 factors activate genes Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Iris color (a* coordinate) ( 30895295) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
Interacting Genes		10 interacting genes: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 SPHK1 TNFRSF14 TNFSF11 ZBED8
Entrez ID		8720
HPRD ID		04522
Ensembl ID		ENSG00000140943
Uniprot IDs		Q14703
PDB IDs
Enriched GO Terms of Interacting Partners?
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