MADD

Description		MAP kinase activating death domain
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Integral Component Of Membrane Axon
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Activation Of Protein Kinase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) C-reactive protein levels ( 30388399) Chronic kidney disease ( 26831199) Chronotype ( 30696823) Corneal astigmatism ( 29422769) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679 34059833) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 29891935) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol ( 19060911 25961943) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Insulin-related traits (multivariate analysis) ( 32002517) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Monocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Proinsulin levels ( 21873549) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: NPDC1 PIDD1 POT1 PTPRN RB1CC1 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		8567
HPRD ID		04664
Ensembl ID		ENSG00000110514
Uniprot IDs		A0A0A0MRB5 Q8WXG6
PDB IDs
Enriched GO Terms of Interacting Partners?
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