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BRCC3

Description BRCA1/BRCA2-containing complex subunit 3
Image
GO Annotations Cellular Component
  • Ubiquitin Ligase Complex
  • Nuclear Ubiquitin Ligase Complex
  • Spindle Pole
  • Nucleus
  • Nucleoplasm
  • Cytoplasm
  • Cytosol
  • BRCA1-A Complex
  • BRISC Complex
Molecular Function
  • Thiol-dependent Deubiquitinase
  • Protein Binding
  • Metallopeptidase Activity
  • Enzyme Regulator Activity
  • Polyubiquitin Modification-dependent Protein Binding
  • Metal Ion Binding
  • Lys63-specific Deubiquitinase Activity
  • Isopeptidase Activity
Biological Process
  • Double-strand Break Repair
  • Mitotic G2 DNA Damage Checkpoint Signaling
  • Response To X-ray
  • Response To Ionizing Radiation
  • Protein Deubiquitination
  • Positive Regulation Of DNA Repair
  • Regulation Of Catalytic Activity
  • Cell Division
  • Protein K63-linked Deubiquitination
  • Histone H2A K63-linked Deubiquitination
Pathways
  • Metalloprotease DUBs
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Nonhomologous End-Joining (NHEJ)
  • Processing of DNA double-strand break ends
  • G2/M DNA damage checkpoint
Drugs
  • Zinc
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
Diseases
GWAS
  • Venous thromboembolism ( 31676865)
Interacting Genes 12 interacting genes: ANKRD11 BRCA1 FANCG ICOS IFNAR1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1 UIMC1
Entrez ID 79184
HPRD ID 06465
Ensembl ID ENSG00000185515
Uniprot IDs P46736
PDB IDs 6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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