TLE4

Description		TLE family member 4, transcriptional corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Transcription Corepressor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Biological_process Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Leukemia Inhibitory Factor
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Bipolar disorder ( 34099189) Bipolar disorder x sex interaction ( 34099189) Chronotype ( 30696823) Daytime nap ( 33568662) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting insulin ( 34059833) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Motion sickness ( 25628336) Neutrophil percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 22885922 24509480 30297969 26818947 32499647 30718926 28869590)
Interacting Genes		10 interacting genes: BRCA1 CUX1 LIG4 MSX1 NUP62 OTX1 OTX2 PAX5 POU2F1 SRPK2
Entrez ID		7091
HPRD ID		05502
Ensembl ID		ENSG00000106829
Uniprot IDs		Q04727
PDB IDs
Enriched GO Terms of Interacting Partners?
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