SHMT1

Description		serine hydroxymethyltransferase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Small Molecule Binding Identical Protein Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding
	Biological Process	Glycine Metabolic Process L-serine Metabolic Process L-serine Catabolic Process One-carbon Metabolic Process Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Homotetramerization Cellular Response To Tetrahydrofolate Cellular Response To Leukemia Inhibitory Factor
Pathways		Metabolism of folate and pterines Carnitine synthesis
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-formyl-tetrahydrofolate 5-hydroxymethyl-5,6-dihydrofolic acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Blood protein levels ( 30072576) Change in neurofilament light levels ( 31295725) Multiple sclerosis ( 27386562) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: CSNK2B DDX6 DEDD DLEU1 FBXO7 GORASP2 MAPK9 MDFI PIM1 PRSS23 SULT1A3
Entrez ID		6470
HPRD ID		01643
Ensembl ID		ENSG00000176974
Uniprot IDs		P34896
PDB IDs		1BJ4 6FL5 6M5W
Enriched GO Terms of Interacting Partners?
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