TRPV4

Description		transient receptor potential cation channel subfamily V member 4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane
	Molecular Function	Actin Binding Osmosensor Activity Protein Kinase C Binding Ion Channel Activity Cation Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Microtubule Binding Lipid Binding Stretch-activated, Cation-selective, Calcium Channel Activity Protein Kinase Binding SH2 Domain Binding Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Diet Induced Thermogenesis Calcium Ion Transport Cellular Calcium Ion Homeostasis Cell Volume Homeostasis Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Neuron Projection Development Vasopressin Secretion Positive Regulation Of Microtubule Depolymerization Actin Cytoskeleton Reorganization Positive Regulation Of Interleukin-6 Production Response To Insulin Cellular Response To Heat Hyperosmotic Salinity Response Glucose Homeostasis Positive Regulation Of Vascular Permeability Cortical Microtubule Organization Positive Regulation Of Striated Muscle Contraction Positive Regulation Of JNK Cascade Microtubule Polymerization Regulation Of Response To Osmotic Stress Positive Regulation Of Inflammatory Response Multicellular Organismal Water Homeostasis Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response Cellular Hypotonic Salinity Response Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Energy Homeostasis Blood Vessel Endothelial Cell Delamination Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Negative Regulation Of Brown Fat Cell Differentiation Regulation Of Aerobic Respiration Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		TRP channels
Drugs		Cannabidiol Butamben Medical Cannabis Nabiximols
Diseases
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		14 interacting genes: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1
Entrez ID		59341
HPRD ID		05667
Ensembl ID		ENSG00000111199
Uniprot IDs		Q9HBA0
PDB IDs		4DX1 4DX2
Enriched GO Terms of Interacting Partners?
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