SMYD2

Description		SET and MYND domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Complex Binding P53 Binding Protein Binding Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Development Negative Regulation Of Cell Population Proliferation Histone H3-K36 Methylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator
Pathways		PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Age at first sexual intercourse ( 34211149) Diverticular disease ( 30177863) Rheumatic heart disease ( 34106200) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		7 interacting genes: BTF3L4 ESR1 H3C14 HSP90AA1 RB1 SNX11 TP53
Entrez ID		56950
HPRD ID		15406
Ensembl ID		ENSG00000143499
Uniprot IDs		Q9NRG4
PDB IDs		3RIB 3S7B 3S7D 3S7F 3S7J 3TG4 3TG5 4O6F 4WUY 4YND 5ARF 5ARG 5KJK 5KJL 5KJM 5KJN 5V3H 5WCG 6CBX 6CBY 6MON 6N3G
Enriched GO Terms of Interacting Partners?
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