PPP2R5B

Description		protein phosphatase 2 regulatory subunit B'beta
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Protein Dephosphorylation Signal Transduction Regulation Of Signaling Receptor Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Autophosphorylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of G0 To G1 Transition Cellular Response To Growth Factor Stimulus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion XBP1(S) activates chaperone genes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Serum uric acid levels ( 32514006)
Interacting Genes		8 interacting genes: AXIN1 CHEK2 IER3 MAPK1 MARK2 PPP2CA PPP2R1A SGO1
Entrez ID		5526
HPRD ID		09038
Ensembl ID		ENSG00000068971
Uniprot IDs		A0A024R593 Q15173
PDB IDs
Enriched GO Terms of Interacting Partners?
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