DLL4

Description		delta like canonical Notch ligand 4
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Blood Vessel Remodeling Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Pericardium Morphogenesis Signal Transduction Notch Signaling Pathway Visual Perception Blood Circulation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Dorsal Aorta Morphogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Regulation Of Neurogenesis Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Neural Retina Development Notch Signaling Involved In Heart Development Blood Vessel Lumenization Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		3 interacting genes: NOTCH1 NOTCH4 PAK6
Entrez ID		54567
HPRD ID		05540
Ensembl ID		ENSG00000128917
Uniprot IDs		Q9NR61
PDB IDs		5MVX
Enriched GO Terms of Interacting Partners?
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