ERAP1

Description		endoplasmic reticulum aminopeptidase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Metalloexopeptidase Activity Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity
	Biological Process	Angiogenesis Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Proteolysis Membrane Protein Ectodomain Proteolysis Signal Transduction Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis
Pathways		Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 32492107 25200001) Alcohol dependence ( 19581569) Ankylosing spondylitis ( 23749187 21743469 20062062 30946743) Behcet's disease ( 23291587) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971 29273807) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 25990418) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Medication use (calcium channel blockers) ( 31015401) Psoriasis ( 25854761 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Systolic blood pressure ( 30578418) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		3 interacting genes: H3-4 IL6R TNFRSF1A
Entrez ID		51752
HPRD ID		06015
Ensembl ID		ENSG00000164307
Uniprot IDs		Q9NZ08
PDB IDs		2YD0 3MDJ 3QNF 3RJO 5J5E 6M8P 6MGQ 6Q4R 6RQX 6RYF 6T6R
Enriched GO Terms of Interacting Partners?
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