EIF2AK4

Description		eukaryotic translation initiation factor 2 alpha kinase 4
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GO Annotations	Cellular Component	Cytosol Polysome Cytosolic Ribosome
	Molecular Function	TRNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Protein Serine Kinase Activity
	Biological Process	DNA Damage Checkpoint Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Activation Involved In Immune Response Positive Regulation Of Adaptive Immune Response Regulation Of Translational Initiation Protein Phosphorylation Cell Cycle Learning Long-term Memory Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Viral Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of CREB Transcription Factor Activity Cellular Response To Amino Acid Starvation Cellular Response To UV EiF2alpha Phosphorylation In Response To Endoplasmic Reticulum Stress Negative Regulation By Host Of Viral Genome Replication Negative Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Protein Autophosphorylation Defense Response To Virus Regulation Of Feeding Behavior Cellular Response To Cold Positive Regulation Of Translational Initiation In Response To Starvation GCN2-mediated Signaling Positive Regulation Of Long-term Synaptic Potentiation Neuron Projection Extension Cellular Response To Leucine Starvation
Pathways		Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs		Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Body mass index ( 24827717) Corneal curvature ( 22969067) Diastolic blood pressure ( 27841878) Ewing sarcoma ( 22327514) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Response to haloperidol in psychosis ( 24751813) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		4 interacting genes: GGNBP1 SMAD1 SMAD4 TGFBR1
Entrez ID		440275
HPRD ID		18447
Ensembl ID		ENSG00000128829
Uniprot IDs		Q9P2K8
PDB IDs		6N3L 6N3N 6N3O
Enriched GO Terms of Interacting Partners?
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