LIG3

Description		DNA ligase 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Ligation Lagging Strand Elongation Base-excision Repair, Gap-filling Base-excision Repair, DNA Ligation Double-strand Break Repair Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs		Bleomycin
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiographic traits (multivariate) ( 32602732) Night sleep phenotypes ( 27126917) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 19305408 29874175) TPE interval (resting) ( 32386560)
Interacting Genes		8 interacting genes: APP JTB NEIL1 PARP1 TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		3980
HPRD ID		02966
Ensembl ID		ENSG00000005156
Uniprot IDs		P49916
PDB IDs		1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG 6WH1
Enriched GO Terms of Interacting Partners?
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