KCNK3

Description		potassium two pore domain channel subfamily K member 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	Ion Channel Activity Open Rectifier Potassium Channel Activity Potassium Channel Activity Protein C-terminus Binding Potassium Ion Leak Channel Activity S100 Protein Binding
	Biological Process	Potassium Ion Transport Chemical Synaptic Transmission Brain Development Response To Xenobiotic Stimulus Stabilization Of Membrane Potential Ion Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Zinc Ion Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Cochlea Development
Pathways		TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential
Drugs		Doxapram Halothane
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27736895 27841878 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Hand grip strength ( 29691431) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) Hypertension ( 31879980 30487518) Ischemic stroke ( 29531354) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 26390057 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Potassium levels ( 29403010) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Stroke ( 29531354) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 29403010 28739976 27618452 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549)
Interacting Genes		9 interacting genes: COPB1 S100A10 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		3777
HPRD ID		04451
Ensembl ID		ENSG00000171303
Uniprot IDs		O14649
PDB IDs		6RV2 6RV3 6RV4
Enriched GO Terms of Interacting Partners?
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